Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RAP2B contributors: mct - updated : 24-04-2009
HGNC name RAP2B, member of RAS oncogene family
HGNC id 9862
Location 3q25.2      Physical location : 152.880.028 - 152.886.261
Synonym name
  • Ras-related protein RAP-2B
  • small GTP binding protein
  • Ras family small GTP binding protein RAP2B
  • Synonym symbol(s) MGC20484
    DNA
    TYPE functioning gene
    STRUCTURE 6.23 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TRALPUSH 3q25.1 TRALPUSH H963 3q25.1 TRALPUSH GPR105 3q21-q25 G protein-coupled receptor 105 GPR87 3q24 G protein-coupled receptor 87 GPR86 3q24 G protein-coupled receptor 86 P2RY12 3q24-q25 purinergic receptor P2Y, G-protein coupled, 12 FLJ25972 3q25.1 hypothetical protein FLJ25972 LOC344752 3q25.1 similar to Arylacetamide deacetylase LOC201651 3q25.1 similar to esterase/N-deacetylase (EC 3.5.1.-), 50K hepatic - rabbit AADAC 3q21.3-q25.2 arylacetamide deacetylase (esterase) GPR91 3q24-3q25.1 G protein-coupled receptor 91 MBNL1 3q25.1-q25.2 muscleblind-like (Drosophila) P2RY1 3q25 purinergic receptor P2Y, G-protein coupled, 1 RAP2B 3q25.2 RAP2B, member of RAS oncogene family LOC152118 3q25.2 hypothetical gene supported by AF086445 DKFZP434D146 3q25.2 DKFZP434D146 protein RH_II/GuBp2 3q25.2 similar to orphan seven transmembrane receptor DHX36 3q25 DEAH (Asp-Glu-Ala-His) box polypeptide 36 GPR149 3q25.2 G protein-coupled receptor 149 MME 3q25.1-q25.2 membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) LOC256283 3q25.2 hypothetical LOC256283
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 6237 20.3 183 - Farrell (1990)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
    Visualeyeanterior segment   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated LipoP
    HOMOLOGY
    interspecies ortholog to murine Rap2b
    homolog to rattus Rap2b
    Homologene
    FAMILY
  • small GTPase superfamily
  • RAS family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    text localizing and recruiting TNIK to the recycling endosomes in a palmitoylation dependent manner (Uechi 2009)
    basic FUNCTION
  • may be involved in small GTPase mediated signal transduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • GTP binding
  • protein
  • MINK1 interaction with RAP2B plays a critical role in maintaining the morphological integrity of dendrites and synaptic transmission
  • cell & other
    REGULATION
    Other requires palmitoylation for induction of TNIK-mediated phenotype, the suppression of cell spreading (Uechi 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in DMD milder phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS