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FLASH GENE
Symbol RAP1B contributors: mct - updated : 22-09-2016
HGNC name RAP1B, member of RAS oncogene family
HGNC id 9857
Location 12q15      Physical location : 69.004.651 - 69.054.377
Synonym symbol(s) KREV, EVI105, RAPB
DNA
TYPE functioning gene
STRUCTURE 49.77 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2172 20.8 184 - 2002 1208914
8 - 2163 20.8 184 - 2002 1208914
6 - 2046 - 142 - 2002 1208914
7 - 2022 - 137 - 2002 1208914
6 - 2037 - 142 - 2002 1208914
7 - 2106 - 165 - 2002 1208914
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Reproductivemale systemprostate  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunenatural killer Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Rap1b
Homologene
FAMILY RAS protein, RAB subfamily
CATEGORY signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
text shuttle between plasma membrane and cytosol
basic FUNCTION
  • implicated in the transduction of the cAMP mitogenic signal
  • RAP1B ameliorates glucose-induced mitochondrial dysfunction in renal tubular cells
  • role for RAP1B in NK cell signaling and effector functions
  • functions of RAP1B in platelet secretion and in integrin ITGA2B, ITGB3 outside-in signaling
  • RAP1B in both smooth muscle and endothelium plays a key role in maintaining blood pressure by controlling normal vascular tone
  • unexpected role for RAP1B as a key suppressor of neutrophil migration and lung inflammation
  • small GTPase involved in the regulation of numerous cellular processes including synaptic plasticity, one of the bases of memory
  • is a small GTPase that suppresses the metastasis of breast cancer cells by increasing cell-cell adhesion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with RAPGEF4
  • RGL2 is a potential effector for RAS and the RAS analogue RAP1B
  • MTOR pathway is required to counteract the SMURF2-initiated degradation of RAP1B during the establishment of neuronal polarity
  • upon activation, RAP1B colocalized with the scaffolding protein IQGAP1
  • specific activation of RAP1B contributes to neuronal polarization via interaction with RALA and RASSF5 in addition to PI3-kinase
  • inhibitory action of RAP1B on PI3K signaling may be mediated by activation of phosphatase PTPN6
  • RRAS2 is essential for CD36-FCER1G-mediated platelet activation and for thrombus stability via control of RAP1B and integrins
    • cell & other
    REGULATION
    activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    decrease in RAP1B prenylation and subsequent loss of RAP1B at the plasma membrane decreases cell-cell adhesion and increases cell scattering, which promotes the metastatic phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rap1b-deficient mice exhibited enhanced neutrophil recruitment to inflamed lungs and enhanced susceptibility to endotoxin shock
  • Rap1b(-/-) mice developed cardiac hypertrophy and elevated blood pressure, but maintained a normal heart rate