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FLASH GENE
Symbol RANGRF contributors: mct - updated : 20-10-2007
HGNC name RAN guanine nucleotide release factor
HGNC id 17679
Location 17p13      Physical location : 8.191.968 - 8.193.408
Synonym name yeast MOG1 homolog
Synonym symbol(s) HSPC165, HSPC236, MGC110973, MOG1, RANGNRF
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 1.00 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 847 - 186 - Steggerda (2001)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheartatrium  predominantly
 heartventricle  predominantly
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
 tonsils   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiacmyocardium 
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast Mog1
Homologene
FAMILY
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
text shuttles between the nucleus and the cytoplasm
basic FUNCTION
  • regulates the nuclear transport functions of RAN
  • evolutionarily conserved RAN binding protein that could play a role in regulating nuclear protein trafficking
  • functioning not only for nuclear import but also for RNA metabolism and signal transduction
  • central component of the channel complex and modulates the physiological function of SCN5A, regulating the proper expression and function of SCN5A in cardiomyocytes
  • play a regulatory role in nuclear import and export by maintaining the Ran-GTP gradient from the nuclei to the cytoplasm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text regulation of nuclear protein trafficking
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds RanGTP and stimulates guanine nucleotide release
  • co-factor for SCN5A and modulates the appropriate expression and function of SCN5A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS