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FLASH GENE

Symbol

RANBP3

contributors: mct/npt/pgu - updated : 31-05-2013

HGNC name	RAN binding protein 3
HGNC id	9850

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 5.916.153 - 5.978.320
Synonym symbol(s)	DKFZp586I1520

DNA

TYPE	functioning gene
STRUCTURE	62.17 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

tentative : very preliminary evidence

Map	pter - D19S209 - EEF2 - FKBP3 - TBXA2R TBXA2R - FUT3 - RANBP3 - D19S216 ,GTF2F1 - EMR1 - D19S912 - cen
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003624 17 - 3400 NP_003615 59.5 562 - 1998 9637251 NM_007320 15 - 3211 NP_015559 53.3 499 - 1998 9637251 RANBP-3B variant c - - 2672 23.8 221 - 1998 9637251 lacking the N terminal region of a and b NM_007322 17 - 3415 NP_015561 60.1 567 - 1998 9637251 truncated 3'UTR RANBP-3D

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	FXFG motifs characteristic of a subgroup of nucleoporins
	a C terminal domain with similarity to RANBP1

HOMOLOGY

Homologene

FAMILY

CATEGORY

chaperone/stress , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	scaffold protein promoting the efficient assembly of the nuclear export complex
	nuclear effector of the RAN pathway
	is a direct export enhancer for beta-catenin, independent of its role as a XPO1-associated nuclear export cofactor
	playing a role in mediating SMAD2/3 nuclear export and terminating TGF-beta signaling
	acts as a XPO1 cofactor, enhancing NES export by stabilizing the export complex in the nucleus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

nuclear export complex

INTERACTION

DNA

RNA

small molecule

protein	linking exportin 1 (XPO1) to the regulator of chromosome condensation 1, CHC1 (RCC1)
	RAN binding
	preferentially bound to importin alpha 3 (KPNA4)
	XPO1-mediated export is regulated by RANBP3, a Ran-interacting nuclear protein
	PPM1A directly interacted with and dephosphorylated RANBP3 at Ser 58

cell & other

REGULATION

Other

its phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS