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FLASH GENE
Symbol RANBP10 contributors: mct - updated : 05-04-2008
HGNC name RAN binding protein 10
HGNC id 29285
Location 16q22.1      Physical location : 67.757.005 - 67.840.555
Synonym symbol(s) FLJ31165, KIAA1464
DNA
TYPE functioning gene
STRUCTURE 83.55 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 5305 - 620 - 2006 16498413
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Nervousnerve   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SPRY domain
  • a LisH-CTLH and CRA motifs
  • HOMOLOGY
    intraspecies homolog to RANBP9 (highly)
    Homologene
    FAMILY
  • Scorpin family
  • RANBP9/10 family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • enhancing the ligand-dependent transcriptional activity of AR and forms a complex with AR
  • enhancing AR transactivation as a homo-oligomer or a hetero-oligomer with RANBP9
  • might serve as a molecular link between Ran and noncentrosomal microtubules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a protein complex with itself or RANBP9
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with RANBP9 (interacts with the tyrosine kinase domain of MET via its SPRY domain and these two proteins can compete with each other to bind to MET, exhibiting a competitive effect on the MET signaling cascade)
  • binding beta-tubulin
  • associating with megakaryocyte microtubules
  • YPEL5-binding protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS