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FLASH GENE
Symbol RANBP1 contributors: mct/npt - updated : 05-03-2010
HGNC name RAN binding protein 1
HGNC id 9847
Location 22q11.21      Physical location : 20.105.023 - 20.114.704
Synonym symbol(s) MGC88701, HTF9A
DNA
TYPE functioning gene
STRUCTURE 9.68 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 884 - 201 - Tedeschi (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrain  highly
 brainforebrain  predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
cell cycle     cell cycle, G2
Text embryonic brain ventricular zone, in the frontonasal
processes, branchial arches, aortic arches, and limb buds (Maynard 2002)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a region sharing homogeneity with cAMP dependent protein kinase
  • a RanBD1 domaain
  • a nuclear export signal sharing homoloigy with the NES of the inhibitor of cAMP dependent protein kinase
    • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Ranbp1
    homolog to C.elegans k05f1.9
    Homologene
    FAMILY
  • Ras-related small nuclear protein (RANBP1) family
    • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inhibiting GTP dissociation
  • increasing GTP hydrolysis by the RAN GTPase activating protein (RANGAP1)
  • regulates centrosome cohesion during mitosis (Di Fiore 2003)
  • regulator of RCC1 (regulator of chromatin condesation 1)
  • has an established role in spindle assembly and in mitotic progression (Tedeschi 2007)
  • its activity is required for the proper localization of specific factors that regulate microtubule function; loss of this activity contributes to the generation of aneuploidy in a microtubule-dependent manner (Tedeschi 2007)
  • contributes to regulate the function of the mitotic apparatus (Rensen 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a trimeric complex with RANGAP1,RANBP7 or RANBP8
  • forming a trimeric complex with Ran-GDP and importin-beta, and RANBP1 restores the GDP nucleotide exchange by importin-beta by forming a tetrameric complex with importin-beta, Ran, and importin-alpha (Lonhienne 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Ran complexed with GTP specifically (not GDP)
  • interacts with importin-beta, but this interaction is weaker than the Ran-GTP/importin-beta interaction (Lonhienne 2009)
  • interacting with RANBP1 and RANGAP1 (phosphorylation of RANGAP1 stabilizes its interaction with RAN and RANBP1) (Takeda 2005)
  • binds RAN and regulates its interaction with effectors (Rensen 2009)
  • interacting with RAN and RANGAP1 (phosphorylation of RANGAP1 stabilizes its interaction with RAN and RANBP1) (Takeda 2005)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    sensitizes cancer cells to taxol in a caspase-3-dependent manner, and can modulate the outcome of mitotic microtubule-targeting therapeutic protocols (Rensen 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene velocardiofacial syndrome/DiGeorge syndrome candidate gene (Maynard 2002)
    Marker
    Therapy target
    ANIMAL & CELL MODELS