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FLASH GENE
Symbol RAMP2 contributors: mct/npt - updated : 12-06-2013
HGNC name receptor (G protein-coupled) activity modifying protein 2
HGNC id 9844
Location 17q21.31      Physical location : 40.913.211 - 40.915.057
Synonym name
  • calcitonin receptor-like receptor activity modifying protein 2
  • receptor (calcitonin) activity modifying protein 2
  • CRLR activity-modifying protein 2
  • DNA
    TYPE functioning gene
    STRUCTURE 1.85 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    STAT5A 17q11.2 signal transducer and activator of transcription 5A MGC16063 17q21.31 hypothetical protein MGC16063 STAT3 17q21 signal transducer and activator of transcription 3 (acute-phase response factor) PTRF 17q21.2 polymerase I and transcript release factor ATP6V0A1 17q21.3 ATPase, H+ transporting, lysosomal V0 subunit a isoform 1 NAGLU 17q21.1 N-acetylglucosaminidase, alpha- (Sanfilippo disease IIIB) HSD17BP1 17q11-q21 hydroxysteroid (17-beta) dehydrogenase pseudogene 1 HSD17B1 17q21.1 hydroxysteroid (17-beta) dehydrogenase 1 DPCK 17q12-q21 bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase TCFL4 17q21.1 transcription factor-like 4 HUMGT198A 17q12-q21 GT198, complete ORF LOC162427 17q21.31 hypothetical protein LOC162427 TUBG1 17q21 tubulin, gamma 1 LOC342578 17q21.31 similar to high mobility group protein homolog HMG4 TUBG2 17q21 tubulin, gamma 2 FLJ21019 17q21.31 hypothetical protein FLJ21019 GPR2 17q21.1 G protein-coupled receptor 2 CNTNAP1 17q21 contactin associated protein 1 EZH1 17q21 enhancer of zeste homolog 1 (Drosophila) RAMP2 17q12-q21.1 receptor (calcitonin) activity modifying protein 2 MGC10540 17q21.31 hypothetical protein MGC10540 PRKWNK4 17q12 protein kinase, lysine deficient 4 HSPC009 17q21 HSPC009 protein FLJ40137 17q21.31 hypothetical protein FLJ40137 BECN1 17q21 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) PSME3 17q21 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) AOC2 17q21 amine oxidase, copper containing 2 (retina-specific) AOC3 17q21 amine oxidase, copper containing 3 (vascular adhesion protein 1) LOC90586 17q21.31 amine oxidase pseudogene LOC388387 17 hypothetical gene supported by AK055784 G6PC 17q21 glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease) MGC2744 17q21.31 hypothetical protein MGC2744 DKFZp761H0421 17q21.31 hypothetical protein DKFZp761H0421 RPL27 17q21 ribosomal protein L27 IFI35 17q21 interferon-induced protein 35 VAT1 17q21 vesicle amine transport protein 1 homolog (T californica) ARHN 17q21 ras homolog gene family, member N BRCA1 17q21 breast cancer 1, early onset
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 808 19 175 - 2000 11060459
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Lymphoid/Immunespleen    
    Reproductivefemale systemplacenta   
    Respiratorylung     Homo sapiensFetal
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four N terminal cysteine conserved residues
  • a basic-acid pair of residues at C terminus
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to RAMP1
    homolog to RAMP3
    Homologene
    FAMILY
  • RAMP family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • transporting calcitonin receptor-like receptor (CALCRL) to cell surface
  • is a key determinant of the effects of ADM on the vasculature and is essential for angiogenesis and vascular integrity
  • enables calcitonin receptor-like receptor (CALCRL) to form an adrenomedullin (ADM)-specific receptor
  • RAMP2 and RAMP3 enable calcitonin receptor-like receptor (CLR) to function as two heterodimeric receptors (CLR/RAMP2 and CLR/RAMP3) for adrenomedullin (ADM), a potent cardiovascular protective peptide
  • ADM receptor components CALCRL and RAMP2 gene expression increased with increasing gestational age
  • ADM-RAMP2 system suppresses ER stress-induced tubule cell death, thereby exerting a protective effect on kidney
  • having a broad regulatory role in receptor trafficking
  • essential roles in vascular development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • ADM-RAMP2 system is a key determinant of vascular integrity and homeostasis from prenatal stages through adulthood
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding with CALCRL to reconstitute ADM receptor
  • CALCRL heterodimerize with RAMP2 and serves as the adrenomedullin (AM) receptor to control neovascularization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in a majority of lung tumors, correlated with high tumor grade
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS