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FLASH GENE
Symbol RAMP1 contributors: mct - updated : 01-02-2008
HGNC name receptor (calcitonin) activity modifying protein 1
HGNC id 9843
Location 2q36-q37.1      Physical location : 238.768.186 - 238.820.753
Synonym name
  • calcitonin receptor-like receptor activity modifying protein 1
  • receptor (calcitonin) activity modifying protein 1
  • receptor activity modifying protein 1
  • DNA
    TYPE like-sequence
    STRUCTURE 52.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 922 - 148 - Heroux (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon   Homo sapiensmRNA
     intestinesmall intestine    Homo sapiensmRNA
     stomach     Homo sapiensmRNA
    Nervousbrainhindbraincerebellum highly Rattus norvegicus
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four N terminal extra cysteine conserved residues
  • a transmembrane segment (TM1)
  • a cytoplasmic tail with a basic pair of residues
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to RAMP2,RAMP3
    Homologene
    FAMILY RAMP family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transporting calcitonin receptor-like receptor (CRLR) to cell surface
  • accessory protein of the G protein-coupled calcitonin receptor-like receptor
  • playing a role beyond its established interaction with G protein-coupled receptors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component CLR/RAMP1 heterodimer defines a receptor for the potent vasodilatory calcitonin gene-related peptide
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding with CALCRL to reconstitute CGRP receptor
  • CALCRL acts as a receptor for the calcitonin gene-related peptide (CALCA) but in order to recognize CALCA, it must form a complex with an accessory protein, receptor activity modifying protein 1 (RAMP1)
  • CALCA exerts its diverse effects on vasodilation, nociception, secretion, and motor function through a heterodimeric receptor comprising of CALCRL and receptor activity-modifying protein 1 (RAMP1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS