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FLASH GENE
Symbol RAMP1 contributors: mct - updated : 01-02-2008
HGNC name receptor (calcitonin) activity modifying protein 1
HGNC id 9843
Location 2q36-q37.1      Physical location : 238.768.186 - 238.820.753
Synonym name
  • calcitonin receptor-like receptor activity modifying protein 1
  • receptor (calcitonin) activity modifying protein 1
  • receptor activity modifying protein 1
  • DNA
    TYPE like-sequence
    STRUCTURE 52.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CMKOR1 2q37.3 chemokine orphan receptor 1 COPS8 2q37.3 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) LOC389087 2 LOC389087 COL6A3 2q37.3 collagen, type VI, alpha 3 LOC285110 2q37.3 hypothetical LOC285110 MLPH 2q37.3 hypothetical LOC285110 PRH 2q37.3 preproprolactin-releasing peptide RAB17 2q37.3 RAB17, member RAS oncogene family LRRFIP1 2q37.3 leucine rich repeat (in FLII) interacting protein 1 FLJ40411 2q37.3 FLJ40411 protein RAMP1 2q36-q37.1 receptor (calcitonin) activity modifying protein 1 NCE2 2q37.3 NEDD8-conjugating enzyme SCLY 2q37.3 selenocysteine lyase LOC339768 2q37.3 hypothetical protein LOC339768 FLJ43374 2q37.3 FLJ43374 protein LOC389088 2 similar to hypothetical protein 4832406C22 ILKAP 2q37.3 integrin-linked kinase-associated serine/threonine phosphatase 2C LOC151174 2q37.3 hypothetical protein LOC151174 LOC391494 2 similar to TAR DNA-binding protein-43 (TDP-43) HES6 2q37.3 hairy and enhancer of split 6 (Drosophila) PER2 2q37.3 period homolog 2 (Drosophila) MIP-T3 2q37.3 microtubule-interacting protein that associates with TRAF3 ASB1 2q37 ankyrin repeat and SOCS box-containing 1 LOC339771 2q37.3 hypothetical LOC339771 HDAC4 2q37.2 histone deacetylase 4 MGC16025 2q37.3 hypothetical protein MGC16025
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 922 - 148 - Heroux (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon   Homo sapiensmRNA
     intestinesmall intestine    Homo sapiensmRNA
     stomach     Homo sapiensmRNA
    Nervousbrainhindbraincerebellum highly Rattus norvegicus
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four N terminal extra cysteine conserved residues
  • a transmembrane segment (TM1)
  • a cytoplasmic tail with a basic pair of residues
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to RAMP2,RAMP3
    Homologene
    FAMILY RAMP family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transporting calcitonin receptor-like receptor (CRLR) to cell surface
  • accessory protein of the G protein-coupled calcitonin receptor-like receptor
  • playing a role beyond its established interaction with G protein-coupled receptors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component CLR/RAMP1 heterodimer defines a receptor for the potent vasodilatory calcitonin gene-related peptide
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding with CALCRL to reconstitute CGRP receptor
  • CALCRL acts as a receptor for the calcitonin gene-related peptide (CALCA) but in order to recognize CALCA, it must form a complex with an accessory protein, receptor activity modifying protein 1 (RAMP1)
  • CALCA exerts its diverse effects on vasodilation, nociception, secretion, and motor function through a heterodimeric receptor comprising of CALCRL and receptor activity-modifying protein 1 (RAMP1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS