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FLASH GENE
Symbol RALY contributors: mct - updated : 16-09-2014
HGNC name RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow)
HGNC id 15921
Location 20q11.22      Physical location : 32.581.731 - 32.668.065
Synonym symbol(s) P542, HNRPCL2
DNA
TYPE functioning gene
STRUCTURE 89.53 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
Physical map
C20orf70 20q11.21 chromosome 20 open reading frame 70 SOCS2P1 20 suppressor of cytokine signaling 2 pseudogene 1 BASE 20q11.21 suppressor of cytokine signaling 2 pseudogene 1 C20orf71 20q11.22 chromosome 20 open reading frame 71 PLUNC 20p11.1-q12 palate, lung and nasal epithelium carcinoma associated RPL12P3 20q11.21 ribosomal protein L12 pseudogene 3 C20orf114 20q11.23 chromosome 20 open reading frame 114 CDK5RAP1 20pter-q11.23 CDK5 regulatory subunit associated protein 1 SNTA1 20q11.2 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) CBFA2T2 20q11.21-q11.23 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 APBA2BP 20q11.21 amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein C20orf144 20q11.21 chromosome 20 open reading frame 144 E2F1 20q11 E2F transcription factor 1 PXMP4 20q11.21 peroxisomal membrane protein 4, 24kDa ZNF341 20q11.21 zinc finger protein 341 RPL31P2 20q11.2 ribosomal protein L31 pseudogene 2 C20orf178 20q11.22 chromosome 20 open reading frame 178 TPM5P 20q11.2 tropomyosin 5, pseudogene RALY 20q11.21-q11.23 RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow) EIF2S2 20pter-q12 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa LOC391244 20 similar to ribosomal protein S2; 40S ribosomal protein S2 XPOTP1 20q11.21 exportin, tRNA (nuclear export receptor for tRNAs) pseudogene 1 ASIP 20q11.21 agouti signaling protein, nonagouti homolog (mouse) AHCY 20cen-q13.1 S-adenosylhomocysteine hydrolase ITCH 20q11.22-23 itchy homolog E3 ubiquitin protein ligase (mouse) CDC42P1 20q11.22 cell division cycle 42 pseudogene 1 FDXP1 20cen-q13.1 ferredoxin pseudogene 1 FLJ38773 20q11.22 hypothetical protein FLJ38773 DNCL2A 20q12-q13.1 dynein, cytoplasmic, light polypeptide 2A MAP1LC3A 20cen-q13 microtubule-associated protein 1 light chain 3 alpha CDC91L1 20q11.21 CDC91 cell division cycle 91-like 1 (S. cerevisiae)
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4790 - 305 - 2012 22994768
  • RALYL
  • expression of RALYL was significantly low in clear cell renal cell carcinoma and correlated with a poor prognosis in a large number of clinical samples
  • 9 - 4742 - 290 - 2012 22994768
    RALYS
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY heterogeneous nuclear ribonucleoproteins family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in many processes of mRNA metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA-dependent interactions of RALY with MATR3, PABPC1 and ELAVL1
  • protein-protein interaction of RALY with EIF4A3, FMRP, and HNRNPC
  • HNRNPH1, RALY, and TFG are proteins that specifically interact with the C-terminal domain of RBFOX1 and RBFOX2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to facial pigmented spots during aging
  • Variant & Polymorphism other
  • genetic variations in RALY/ASIP, contribute to the acquired amount of facial pigmented spots during aging, through pathways independent of the basal melanin production
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    may be a potential therapeutic target as well as a poor prognostic factor, in clear cell renal cell carcinoma
    ANIMAL & CELL MODELS