| basic FUNCTION
| required to suppress apoptotic checkpoint activation |
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RALA and RALB are important, functionally distinct targets for geranylgeranyltransferase I inhibitors-mediated tumor apoptosis and growth inhibition  |
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mediate both common and specific transcriptional programs that are associated with cancer and identify RREB1 as a novel transcriptional effector of RAL |
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with RALA, make critical non-overlapping contributions to the generation of a tumorigenic regulatory network, supporting bypass of the normal restraints on both cell proliferation and survival |
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required for recruitment of the exocyst to the midbody of this bridge to drive abscission and completion of cytokinesis |
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having a crucial function in the regulatory network that couples extracellular signals with appropriate cellular responses |
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with RALA contribute to KRas-dependent ionizing radiation resistance |
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with its effector EXOC8 are required for nutrient starvation-induced autophagocytosis, and RALB activation is sufficient to promote autophagosome formation |
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can separately engage EXOC8 to facilitate activation of the autophagy kinase ULK1 and induction of autophagosome biogenesis |
