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FLASH GENE
Symbol RAET1E contributors: mct - updated : 16-03-2011
HGNC name retinoic acid early transcript 1E
HGNC id 16793
Location 6q25.1      Physical location : 150.209.600 - 150.212.097
Synonym name
  • lymphocyte effector toxicity activation ligand
  • Synonym symbol(s) LETAL, ULBP4, RAET1E2, MGC125308, MGC125309
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text
  • major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster
  • STRUCTURE 2.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - RAET1F - RAET1G - ULBP2 - ULBP1 - RAET1J - RAET1K - RAET1L - RAET1M - ULBP3 - qter
    Authors Radosavljevic (01)
    Physical map
    SASH1 6q24.3 formyltetrahydrofolate synthetase domain containing 1 LOC340151 6q24.3 similar to laminin receptor 1 (ribosomal protein SA); P40-3, functional; P40-8, functional; laminin receptor 1 (67kD, ribosomal protein SA) UST 6q24.3-q25.1 uronyl-2-sulfotransferase MAP3K7IP2 6q25.1-q25.3 mitogen-activated protein kinase kinase kinase 7 interacting protein 2 LOC340152 6q24.3 similar to hypothetical protein D730019B10 PPIL4 6q24-q25 peptidylprolyl isomerase (cyclophilin)-like 4 C6orf72 6q24.3 chromosome 6 open reading frame 72 LOC389433 6 LOC389433 KATNA1 6q25.1 katanin p60 (ATPase-containing) subunit A 1 LATS1 6q24-q25.1 LATS, large tumor suppressor, homolog 1 (Drosophila) NUP43 6q24.3 nucleoporin 43kDa PCMT1 6q22.3-q24 protein-L-isoaspartate (D-aspartate) O-methyltransferase LRP11 6q24.3 low density lipoprotein receptor-related protein 11 RAET1E 6q25 retinoic acid early transcript 1E ULBP2 6q25 UL16 binding protein 2 ULBP1 6q25 UL16 binding protein 1 LOC345829 6q24.3 similar to Transcription factor BTF3 (RNA polymerase B transcription factor 3) LOC391980 6 similar to UL16 binding protein 1; alcan-beta RAET1L 6q25 retinoic acid early transcript 1L PHBP1 6q25 prohibitin pseudogene 1 ULBP3 6q25 UL16 binding protein 3 PPP1R14C 6q24.3-q25.3 protein phosphatase 1, regulatory (inhibitor) subunit 14C RNU4P1 6q25.1 RNA, U4 small nuclear pseudogene 1 (U4/7) LOC389434 6 similar to iodotyrosine dehalogenase protein PLEKHG1 6q25.1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 FTHFSDC1 6q25.1 formyltetrahydrofolate synthetase domain containing 1 LOC391982 6 similar to ribosomal protein S12 AKAP12 6q24-q25 a kinase (PRKA) anchor protein (gravin) 12
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 885 30 263 - 2008 18544572
    - splicing - - - - 2008 18544572
  • type 1 membrane-spanning molecule having the ability to bind with KLRK1
  • ligand for KLRK1
  • - splicing - - - - 2008 18544572
  • type 1 membrane-spanning molecule having the ability to bind with KLRK1
  • ligand for KLRK1
  • - splicing - - - - 2008 18544572
  • type 1 membrane-spanning molecule having the ability to bind with KLRK1
  • ligand for KLRK1
  • - splicing - - - - 2008 18544572
  • ligand for KLRK1
  • - - 899 35 209 . in different tumor cells and tissues 2007 17470428
  • lacking the transmembrane region by selective splicing in tumor cells
  • may impair KLRK1-mediated NK cell cytotoxicity to tumors
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   predominantly
    Visualeyeanterior segmentcornea  
    cell lineage
    cell lines tumors cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • alpha 1 and alpha 2 domain
  • GPI domain
  • short hydrophilic cytoplasmic tail
  • one immunoglobulin-like domain
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class I superfamily
  • RAET1 family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • single-pass type I membrane protein, membrane-anchored
  • basic FUNCTION
  • stimulating lipid degradation in adipocytes and causing the extensive fat losses associated with some advanced cancers
  • being a ligand for the KLRK1
  • delivering activating signals to NK cells and promoting tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes
  • functions as a ligand for both TCRgammadelta and KLRK1 and may play a key role in immune surveillance of tumor development and clearance of viral infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • antigen processing and presentation
  • PATHWAY
    metabolism
    signaling
    a component
  • MHC class I protein complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to KLRK1/NKG2D
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary ovarian cancers with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS