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FLASH GENE
Symbol RAE1 contributors: mct/npt - updated : 20/10/2008
HGNC name RAE1 RNA export 1 homolog (S. pombe)
HGNC id 9828
Location 20q13.32      Physical location : 55.926.144 - 55.953.518
Synonym name
  • homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer)
  • mRNA export protein
  • mRNA-binding protein, 41-kD
  • mRNA-associated protein MRNP 41
  • Synonym symbol(s) MRNP, GLE2, MRNP41, FLJ30608, MGC117333, MGC126076, MGC126077, MIG14, dJ481F12.3, dJ800J21.1
    DNA
    TYPE functioning gene
    STRUCTURE 27.37 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure expressed from the CMV-promoter
    MAPPING cloned Y linked N status provisional
    Physical map
    C20orf108 20q13.2 chromosome 20 open reading frame 108 STK6 20q13.31 serine/threonine kinase 6 CSTF1 20q13.2-q13.3 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa C20orf32 20q13.31 chromosome 20 open reading frame 32 RPL39P 20q13.2 ribosomal protein L39 pseudogene C20orf43 20q13.31 chromosome 20 open reading frame 43 C20orf106 20q13.2 chromosome 20 open reading frame 106 LOC388799 20 similar to dJ1153D9.4 (novel protein) RPS4L 20q13.2 ribosomal protein S4-like TFAP2C 20q13.2 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) PTMAP6 20 prothymosin, alpha pseudogene 6 LOC388800 20 LOC388800 LOC339583 20q13.31 hypothetical LOC339583 BMP7 20q13.2 bone morphogenetic protein 7 (osteogenic protein 1) LOC284754 20q13.31 hypothetical gene supported by BC037891 SPO11 20q13.2-q13.3 SPO11 meiotic protein covalently bound to DSB-like (S. cerevisiae) RAE1 20q13.31 RAE1 RNA export 1 homolog (S. pombe) RNPC1 20q13.31 RNA-binding region (RNP1, RRM) containing 1 LOC149767 20q13.31 similar to dJ579F20.1 (high-mobility group (nonhistone chromosomal) protein 1-like 1) CTCFL 20q13.31 CCCTC-binding factor (zinc finger protein)-like PCK1 20q13.3 phosphoenolpyruvate carboxykinase 1 (soluble) ZBP1 17q21.3 Z-DNA binding protein 1 TMEPAI 20q13.31-q13.33 transmembrane, prostate androgen induced RNA C20orf85 20q13.32 chromosome 20 open reading frame 85 C20orf86 20q13.32 chromosome 20 open reading frame 86 PPP4R1L 20q13.32 protein phosphatase 4, regulatory subunit 1-like RAB22A 20q13 RAB22A, member RAS oncogene family
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 splicing 1839 41 368 - Wong (2006)
  • differing in the 5' UTR
  • encoding the same protein
  • 12 splicing 1815 41 368 - Wong (2006)
  • differing in the 5' UTR
  • encoding the same protein
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunelymph node   lowly
    Nervousbrain   lowly
    Reproductivefemale systemuteruscervix lowly
     female systemplacenta  lowly
     female systemovary  moderately
     male systemtestis  highly
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin   highly
    Visualeye   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three beta-transducin
  • seven WD40 repeats and is therefore predicted to form a seven-bladed beta-propeller (Ren 2010)
  • mono polymer heteromer
    HOMOLOGY
    interspecies homolog to yeast Rae1
    homolog to murine Rae1
    Homologene
    FAMILY
  • RAE1 family of WD repeat proteins
  • Trp-Asp (WD) repeat proteins proteins
  • CATEGORY RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    intracellular,nuclear envelope,ext
    intracellular,nuclear envelope,pore
    text microtubule-associated protein
    basic FUNCTION
  • involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton
  • required for mitotic spindle assembly
  • may potentially also be directly involved in NUP98 fusion-mediated leukemogenesis, and orchestrates NUP98-mediated leukemogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text nuclear cytoplasmic transport (nuclear import/export), transport of mRNAs from the nucleus to the cytoplasm and attachment of mRNPs to the cytoskeleton
    PATHWAY
    metabolism
    signaling
    pathway that participates in spindle pole formation and that involves recruitment of SMC1A by microtubule-bound RAE1 at the spindle pole
    a component
  • component of the subcomplex C of the nuclear pore complex with NUP98
  • RAE1ĽNUP98 complex has distinct and versatile roles at different stages of the cell cycle, including the nuclear export of mRNAs and the regulation of the cell cycle progression (Ren 2010)
  • INTERACTION
    DNA
    RNA binding to mRNA
    small molecule
    protein
  • actin-cytoskeleton associated NUP98, NXF1, BUB1
  • importin beta
  • interaction with NUMA1 is a critical element for normal spindle formation in mitosis
  • colocalize at spindle pole with SMC1A
  • interaction of RAE1 with the NUP98 GLEBS motif appears to be a critical association for RNA export (Ren 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    targeting the negative feedback loop (RAE1/NUP98) may provide a new strategy for the therapy of aggressive leukemias
    ANIMAL & CELL MODELS