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FLASH GENE
Symbol RADIL contributors: mct - updated : 17-09-2018
HGNC name Ras association and DIL domains
HGNC id 22226
Location 7p22.1      Physical location : 4.838.739 - 4.923.335
Synonym name
  • ras-associating and dilute domain-containing protein
  • Rap GTPase interactor
    • Synonym symbol(s) FLJ10324, KIAA1849, MGC161589, FLJ60975, RASIP2
    DNA
    TYPE functioning gene
    STRUCTURE 86.65 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3682 - 1075 - 2007 PMID: 177043
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   lowly
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   lowly
    Nervousbrainhindbraincerebellum highly
    Reproductivefemale systemovary  moderately
     male systemtestis  highly
    Respiratorylung   moderately
    Urinarykidney   lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain (moderately), liver (lowly)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RAS association domain
  • a PDZ domain
  • a DIL domain
  • one FHA domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Radil (81.8pc)
    homolog to rattus Radil (81.8pc)
    Homologene
    FAMILY
  • RADIL family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text G-betaGamma and activated RAP1A promote the translocation of RADIL to the plasma membrane at sites of cell-matrix contacts
    basic FUNCTION
  • downstream effector of RAP1A required for cell adhesion and migration of neural crest precursors during development
  • RADIL, a novel RAP1A effector, regulates ITGB1, ITGB2 activation and controls neutrophil chemotaxis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of a complex (RAP1A-RADIL) required downstream of receptor stimulation for the activation of integrins and the positive modulation of cell-matrix adhesiveness
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding RAP1A in a GTP-dependent manner
  • KIF14 associates with the PDZ domain of RADIL and negatively regulates RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules
  • RASIP1 cooperates with its close relative RAS-association and dilute domain-containing protein (RADIL) to inhibit RHO-mediated stress fiber formation and induces junctional tightening
  • RAP1A effectors RADIL and RASIP1, together with the RHO GTPase activating protein ARHGAP29, mediate RAP1A-induced inhibition of RHO signaling in the processes of epithelial cell spreading and endothelial barrier function
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS