Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RAD54L contributors: mct/npt - updated : 08-07-2008
HGNC name RAD54-like (S. cerevisiae)
HGNC id 9826
Location 1p32      Physical location : 46.713.366 - 46.744.145
Synonym name
  • RAD54 homolog
  • DNA repair and recombination protein RAD54-like
  • Synonym symbol(s) HR54, HRAD54, HHR54, RAD54A
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 30.00 kb     18 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC15668 1p34.1 hypothetical protein MGC15668 MUTYH 1p34.3-p32.1 mutY homolog (E. coli) TOE1  target of EGR1, member 1 (nuclear) TESK2 1p32 testis-specific kinase 2 LOC126661 1p34.1 hypothetical protein LOC126661 DKFZP564I122 1p34.1 DKFZP564I122 protein PRDX1 1p34.1 peroxiredoxin 1 AKR1A1 1p33-p32 aldo-keto reductase family 1, member A1 (aldehyde reductase) NASP 1p34.1 nuclear autoantigenic sperm protein (histone-binding) FLJ33084 1p34.1 hypothetical protein FLJ33084 SP192 1p34.1 hypothetical protein SP192 LOC51249 1p34.1 hypothetical protein LOC51249 IPP 1p34-p32 intracisternal A particle-promoted polypeptide MAST205 1p33 intracisternal A particle-promoted polypeptide PIK3R3 1p34.1 phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) LOC388627 1 LOC388627 TSPAN-1 1p34.1 tetraspan 1 FLJ20277 RAD54L 1p32 RAD54-like (S. cerevisiae) MUF1 1p34.1 RAD54-like (S. cerevisiae) UQCRH 1p34.1 ubiquinol-cytochrome c reductase hinge protein MGC22960 1p34 MGC22960 gene FAAH 1p35-p34 fatty acid amide hydrolase LOC391036 1 similar to vitamin D3 hydroxylase associated protein LOC388628 1 hypothetical gene supported by BC021746 OTX3 1p34.1 orthodenticle homolog 3 (Drosophila) FLJ32011 1p34.1 hypothetical protein FLJ32011 MKNK1 1p34.1 MAP kinase-interacting serine/threonine kinase 1 MOB3C ATPAF1 1p33-p32.3 ATP synthase mitochondrial F1 complex assembly factor 1 LOC374973 1p34.1 LOC374973 KIAA0494 1pter-p22.1 LOC374973 CYP4B1 1p34-p12 cytochrome P450, family 4, subfamily B, polypeptide 1 LOC388629 1 similar to cytochrome P450 4Z1 CYP4Z2P 1p34.1-p33 cytochrome P450 4Z2 pseudogene CYP4A11 1p36.1-p32.1 cytochrome P450, family 4, subfamily A, polypeptide 11 CYP4X1 1p33 likely ortholog of rat cytochrome P450 4X1
    regionally located localized in a region of high loss of heterozygosity in breast cancer
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3107 84 747 - Sellick (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    cell cycle     cell cycle, checkpoint, G1S
    Text lymphoid development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helicase conserved C terminal domain
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD54
    Homologene
    FAMILY
  • SNF2/RAD54 helicase family
  • RAD52 epistasis group
  • CATEGORY enzyme , DNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • recombinational protein associated with RAD51, involved in nucleotide excision repair of double-strand break and in meiotic recombination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in breast cancer
    Susceptibility
  • to pancreatic cancer
  • to meningiomas
  • Variant & Polymorphism other
  • variants affect clinical prognosis of patients with pancreatic cancer
  • association between the rare T allele and the development of meningeal tumours
  • Candidate gene potential tumor suppressor in parathyroid adenoma (see TSG1J), breast cancer with poor prognosis and oligodendroglioma (see TSG1A)
    Marker
    Therapy target
    ANIMAL & CELL MODELS