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FLASH GENE
Symbol RAD54B contributors: mct/npt - updated : 01-06-2011
HGNC name RAD54 homolog B (S. cerevisiae)
HGNC id 17228
Location 8q22.1      Physical location : 95.384.188 - 95.487.310
Synonym name
  • fibrinogen silencer binding protein
  • RAD54 homolog B
  • Synonym symbol(s) FSBP, RDH54
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 103.12 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • INO80 binds to the promoters of the RAD54B and XRCC3 genes
  • MAPPING cloned Y linked N status provisional
    Physical map
    DKFZp762O076 8q21.3 hypothetical protein DKFZp762O076 CGI-77 8q21.3 CGI-77 protein LOC340451 SLC26A7 8q23 solute carrier family 26, member 7 MRPS16P1 8q21.3 solute carrier family 26, member 7 CBFA2T1 8q22 core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related LOC389675 8 similar to 40S ribosomal protein S26 LOC389676 8 LOC389676 LOC392251 8 similar to KIAA1588 protein LOC137392 8q22.1 similar to CG6405 gene product LOC389677 8 similar to RIKEN cDNA 3000004N20 PRO1905 8q22.1 hypothetical protein PRO1905 MGC26979 8q22.1 hypothetical protein MGC26979 LOC157667 8q22.1 similar to myosin regulatory light chain-like PPM2C 8q22.1 protein phosphatase 2C, magnesium-dependent, catalytic subunit CDH17 8q22.1 cadherin 17, LI cadherin (liver-intestine) GEM 8q22.3 GTP binding protein overexpressed in skeletal muscle LOC392252 8 similar to ribosomal protein S4, X-linked RAD54B 8q21.3-q22 similar to ribosomal protein S4, X-linked FSBP 8q22.1 fibrinogen silencer binding protein DKFZP434I116 8q22.1 DKFZP434I116 protein FLJ20171 8q22.1 hypothetical protein FLJ20171 LOC286148 8q22.1 hypothetical protein LOC286148 FLJ20530 8q22.1 hypothetical protein FLJ20530 CCNE2 8q22.1 cyclin E2 LOC392253 8 similar to Ac2-210 TP53INP1 8q22 tumor protein p53 inducible nuclear protein 1 MGC40214 8q22.1 hypothetical protein MGC40214 PLEKHF2 8q22.1 pleckstrin homology domain containing, family F (with FYVE domain) member 2 LOC157657 8q22.1 hypothetical protein LOC157657 LOC392254 8 similar to glyceraldehyde-3-phosphate dehydrogenase LOC392255 8 similar to growth and differentiation factor 6 UQCRB 8q22 ubiquinol-cytochrome c reductase binding protein CGI-12 8q22.1 CGI-12 protein PTDSS1 8q22 phosphatidylserine synthase 1 SDC2 8q22-q23 syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) PGCP 8q22.2 plasma glutamate carboxypeptidase KIAA1750 8q22.1 KIAA1750 protein LOC286150 8q22.1 similar to 40S ribosomal protein S2 LYRIC 8q22.1 LYRIC/3D3 LAPTM4B 8q22.1 lysosomal associated protein transmembrane 4 beta
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3057 103 910 - 2002 11884632
    - - 3097 - 726 - 2002 11884632
    - - 1156 - 117 - 2002 11884632
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal region outside the SWI2/SNF2 domain that shares less conservation with the corresponding region in RAD54, and plays multiple roles of in homologous recombination
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD54P
    homolog to murine Rad54l
    intraspecies homolog to RAD54L
    paralog to RAD54
    Homologene
    FAMILY
  • SNF2/RAD54 helicase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text formed nuclear foci that colocalized with RAD51, RAD54, and BRCA1
    basic FUNCTION
  • participating in homologous recombination pathway (HR)
  • DNA and RNA helicase
  • mitotic and meiotic recombinaition and double-strand break repair
  • may function with the DMC1 recombinase, a meiosis-specific RAD51 homolog
  • may stimulate the DMC1-mediated DNA strand exchange by stabilizing the nucleoprotein filament, which is formed on the ssDNA tails produced at DSB sites during homologous recombination
  • DNA-dependent ATPase, described to be involved in recombinational repair of DNA damage, including DNA double-strand breaks (DSBs)
  • plays important roles in homologous recombination
  • synergizes with the DMC1 recombinase to mediate inter-homologue recombination during meiosis
  • CELLULAR PROCESS nucleotide, repair, recombination
    nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex formation between RAD54B and DMC1 and enhancement of the recombinase activity of DMC1 by RAD54B
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific interaction between S100A11 and RAD54B
  • S10A11 targets RAD54B to sites of DNA DSB repair sites and have a novel function in CDKN1A-based regulation of cell cycle
  • interacting with DMC1 (RAD54B binding may affect the quaternary structure of DMC1)
  • interacting with XRCC3 genes, implicated in DSB repair, to be repressed by INO80 deficiency
  • interacting with INO80 (binds to the promoters of the RAD54B and XRCC3 genes)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    homozygously mutated in primary lymphoma and colon cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS