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FLASH GENE
Symbol RAD51D contributors: mct - updated : 08-09-2016
HGNC name RAD51-like 3 (S. cerevisiae)
HGNC id 9823
Location 17q12      Physical location : -
Synonym name
  • DNA repair protein RAD51 homolog 4
  • Synonym symbol(s) TRAD, R51H3, HsTRAD, RAD51L3, BROVCA4
    DNA
    TYPE functioning gene
    STRUCTURE 20.08 kb     9 Exon(s)
    MAPPING cloned Y linked   status provisional
    Map cen - D17S798 - D17S2139 - RAD51C - D17S822E - D17S1983 - qter
    Authors Pittman (98)
    RNA
    TRANSCRIPTS type messenger
    text two alternatively spliced isoforms, one truncated, one lacking the nucleotide binding motif (Pittman)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2082 - 216 - 2004 1510949
  • V4 or TRAD-D3
  • lacks a 112 AAs internal segment
  • 10 - 2418 - 328 - 2004 1510949
    10 - 2478 - 348 - 2004 1510949
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Reproductivefemale systemuteruscervix highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain (AAs 1-83), which consists of four short helices flanked by long N- and C-terminal tails, is required for the ssDNA-specific binding function of human Rad51D
  • a two ATP binding domains
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD51, D
    intraspecies paralog to RAD51
    Homologene
    FAMILY RAD51 gene family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,telomere
    text to the telomere of the meiotic and somatic cells
    basic FUNCTION
  • likely involved in double strand break repair, recombination and telomere maintenance
  • required for homologous recombination and disruption of Holliday junctions with bloom syndrome protein (BLM)
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair
  • RAD51B, RAD51C, RAD51D, XRCC2, XRCC3 sequentially orchestrate clinically relevant transactions at replication forks, cooperatively promoting fork remodeling and restart
  • CELLULAR PROCESS nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    pathway in cells for the repair of severe DNA damage such as double-strand breaks
    a component
  • member of the BCDX2 protein complex—comprising RAD51B, RAD51C, RAD51D, and XRCC2—which is thought to have several functions in HR, including stabilization of RAD51 nucleoprotein filaments
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • XRCC2 (protection against DNA damaging)
  • HELQ is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    mutations are more likely to be found in families with two or more ovarian cancers, or in probands with first-degree relatives with ovarian cancer
    tumoral germinal mutation      
    germinal deleterious variants in the RAD51 paralogs to breast and ovarian cancers
    Susceptibility to ovarian cancer
    Variant & Polymorphism other RAD51D mutations confer a sixfold increased risk of ovarian cancer
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    cells deficient in RAD51D are sensitive to treatment with a PARP inhibitor, suggesting a possible therapeutic approach for cancers arising in RAD51D mutation carriers
    ANIMAL & CELL MODELS