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FLASH GENE
Symbol RAD51B contributors: mct/pgu - updated : 28-03-2013
HGNC name RAD51-like 1 (S. cerevisiae)
HGNC id 9822
Location 14q24.1      Physical location : -
Synonym name
  • RAD51 homolog B
  • RecA-like protein
  • recombination repair protein
  • DNA repair protein RAD51 homolog 2
  • Synonym symbol(s) REC2, R51H2, hREC2, MGC34245, RAD51L1
    DNA
    TYPE functioning gene
    STRUCTURE 776.11 kb     11 Exon(s)
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1875 38.1 350 - 2003 12441335
    11 - 1566 38.1 350 - 2003 12441335
    11 - 2513 42.1 384 - 2003 12441335
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Endocrinethyroid   highly
    Reproductivefemale systembreastmammary gland highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative nuclear localization signal (NLS)
  • two ATP binding domains (A and B boxes)
  • HOMOLOGY
    interspecies homolog to murine Rad51l1 (85.8pc)
    homolog to rattus Rad51l1 (81.2pc)
    intraspecies paralog to RAD51
    Homologene
    FAMILY
  • recA family
  • RAD51 subfamily
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the homologous recombination repair pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents
  • may promote the assembly of presynaptic RAD51 nucleoprotein filaments
  • RAD51L1-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity
  • may have a specific function in holliday junction processing in the homologous recombinational repair pathway
  • proper biallelic expression is required for the maintenance of chromosome integrity in human cells
  • causing cell cycle G1 delay and cell apoptosis upon overexpression
  • role in sensing DNA damage
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination
  • RAD51B and RAD51C act early in homologous recombination
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, division, mitosis
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    pathway in cells for the repair of severe DNA damage such as double-strand breaks
    a component
  • part of a BCDX2 complex consisting of RAD51L1, RAD51C, RAD51D, XRCC2 and XRCC3
  • part of a complex with RAD51C and RAD51
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • heterodimerizing with RAD51C, which further interacts with RAD51, XRCC2, XRCC3 in the BCDX2 complex
  • cell & other
    REGULATION
    induced by ionizing radiations
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    RAD51L1/HMGIC fusion in uterine leiomyoma in t(12;14)(q15;q24)
    tumoral   translocation    
    translocation t(6;14) (p21.3-q24) in pulmonary chondroid hamartoma
    constitutional     --low  
    haploinsufficiency leads to centrosome fragmentation and aneuploidy
    Susceptibility to male breast cancer
    Variant & Polymorphism SNP
  • SNP associated with breast cancer
  • a SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS