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FLASH GENE
Symbol RAD23A contributors: mct - updated : 07-04-2015
HGNC name RAD23 homolog A (S. cerevisiae)
HGNC id 9812
Location 19p13.2      Physical location : 13.056.653 - 13.064.455
Synonym name yeast RAD23, human homolog A
Synonym symbol(s) HHR23A, HR23A
DNA
TYPE functioning gene
STRUCTURE 7.83 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
MGC26914 19p13.2 hypothetical protein MGC26914 PGK1P2 6p21-p12 phosphoglycerate kinase 1, pseudogene 2 ZNF490 19p13.2 zinc finger protein 490 FLJ90396 19p13.2 hypothetical protein FLJ90396 MGC4238 19p13.2 hypothetical protein MGC4238 LOC284393 19p13.2 similar to 60S ribosomal protein L10 (QM protein homolog) MAN2B1 19p13.2-p13.1 mannosidase, alpha, class 2B, member 1 PTD008 19p13.2 PTD008 protein DHPS 19p13.12-p13.11 deoxyhypusine synthase MGC10870 19p13.2 hypothetical protein MGC10870 TNPO2 19p13.2 transportin 2 (importin 3, karyopherin beta 2b) MGC2803 19p13.2 hypothetical protein MGC2803 ASNA1 19q13.3 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) VMD2L1 19p13.2-p13.12 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) HOOK2 19p13.2 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) RNASEH2A 19p13.2 ribonuclease H2, large subunit JUNB 19p13.2 jun B proto-oncogene PRDX2 13q12 peroxiredoxin 2 RTBDN 19p12 retbindin DNASE2 19p13.2 deoxyribonuclease II, lysosomal KLF1 19p13.13-p13.12 Kruppel-like factor 1 (erythroid) GCDH 19p13.2 glutaryl-Coenzyme A dehydrogenase FARSLA 19p13.2 phenylalanine-tRNA synthetase-like, alpha subunit CALR 19p13.3-p13.2 calreticulin RAD23A 19p13.2 RAD23 homolog A (S. cerevisiae) PLINP-1 19p13.2 papillomavirus L2 interacting nuclear protein 1 FLJ38607 19p13.2 hypothetical protein FLJ38607 LOC339375 19p13.13 hypothetical LOC339375 NFIX 19p13.2 nuclear factor I/X (CCAAT-binding transcription factor) LYL1 19p13.2-p13.1 lymphoblastic leukemia derived sequence 1 FLJ20244 19p13.13 hypothetical protein FLJ20244 BTBD14B 19p13.13 BTB (POZ) domain containing 14B STX10 19p13.2 syntaxin 10 ETR101 LOC390891 19 similar to 60S RIBOSOMAL PROTEIN L12 CACNA1A 19p13.2-13.1 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1821 - 363 - 2005 16105547
8 - 1656 - 308 - 2005 16105547
9 - 1818 - 362 - 2005 16105547
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
 salivary gland   highly
Endocrineparathyroid   highly
Lymphoid/Immunelymph node   highly
Nervousnervecranial nerve  highly
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
Muscularstriatumskeletal predominantly
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a N terminal ubiquitin-like domain
  • a XPC binding domain near the C terminus
  • two ubiquitin-associated (UBA) domains: an internal UBA1 domain and a C-terminal UBA2 domain
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD23,A
    homolog to rattus Rad23a (94.21 pc)
    homolog to murine Rad23a (94.75 pc)
    Homologene
    FAMILY RAD23 family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • ubiquitin conjugating enzyme E3A, involved in the degradation of short-lived and abnormal proteins
  • have redundant roles in DNA repair
  • playing a role in DNA damage recognition in base excision repair and in postreplication repair of UV-damaged DNA
  • regulating the function of XPC by its association with the nucleotide excision repair activator TP53
  • promotes TRAF2 ubiquitin-proteasome dependent degradation
  • could be a novel regulator of antivirus immunity
  • RAD23A, which targets TRAF2 for ubiquitin-proteasome degradation, may play a role in precise control of cellular virus-triggered type I IFNs and proinflammatory cytokines production
  • CELLULAR PROCESS cell cycle
    nucleotide, repair, nucleotide excision repair
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text nucleotide excision repair (NER)
    PATHWAY
    metabolism
    signaling
    a component RAD23A-UBA (2) GFP-loop
    INTERACTION
    DNA single-stranded DNA binding
    RNA
    small molecule
    protein
  • MJD product (ataxin 3) and 26S proteasme by its UBL domain
  • MPG in excision repair pathways
  • HIV1-VPR protein
  • RAD23A, RAD23B facilitate lesion recognition by XPC but do not participate in the downstream DNA repair process
  • RAD23A down-regulated TRAF2 protein level through ubiquitin–proteasome system
  • RAD23A but not its homolog RAD23B, is a negative regulator of DDX58/IFIH1 signaling, and RAD23A was involved in DDX58/IFIH1 signaling through binding to TRAF2
  • might increase TRAF2 ubiquitination by inhibiting its deubiquitylation
  • is required for the nuclear translocation of AIFM1 during induction of cell death, and this process is energy dependent, but independent of karyopherins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS