basic FUNCTION
| plays a crucial role in post-replication repair (PRR) |
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with UBE2B is recruited to stalled replication forks via interactions with forked DNA or long ssDNA structures, a process that is required for initiating post-replication repair |
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accumulates at blocked forks and initiates the signal to recruit translesion DNA synthesis polymerases |
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functions as an adaptor to facilitate homologous recombinaison through direct interaction with the recombinase RAD51C |
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promotes TP53BP1-directed DSB repair by enhancing retention of TP53BP1, possibly through an interaction between RAD18 and TP53BP1 and the modification of TP53BP1 |
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having a rolein the cellular response to DSBs |
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RAD18-mediated PCNA monoubiquitination is a central hub for the mobilization of the FA pathway by promoting FANCL-mediated FANCD2 monoubiquitylation |
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key role for the E3 ligase activity of RAD18 in the recruitment of FANCD2 and FANCI to chromatin and the events leading to their ubiquitylation during S phase |
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at the XY body, RAD18 mediates the chromatin association of its interaction partners, the ubiquitin-conjugating enzymes UBE2A, UBE2B |
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RAD18 and UBE2B have a role in the efficient repair of a small subset of meiotic DSBs |
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ubiquitin ligase involved in replicative damage bypass and DNA double-strand break (DSB) repair processes |
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required for recruitment of RAD9A, one of the components of the 9-1-1 checkpoint complex |
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interacts with ubiquitylated chromatin components and facilitates RAD9A recruitment to DNA double strand breaks |
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is necessary for damage tolerance during S-phase |
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RAD18 and RNF8 operate in the same pathway in the promotion of homologous recombination (HR) |
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involved in post replication repair pathways via its recruitment to stalled replication forks, and its role in the ubiquitylation of proliferating cell nuclear antigen (PCNA) |
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can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure |
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functions at the cross-roads of three different DNA damage response (DDR) pathways involved in protecting stressed replication forks: homologous recombination repair, DNA inter-strand cross-link repair and DNA damage tolerance |
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having hematopoietic functions and confering DNA damage tolerance and tumor-suppression in a physiological setting |