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FLASH GENE
Symbol RAD1 contributors: mlc/pgu - updated : 15-12-2007
HGNC name RAD1 homolog (S. pombe)
HGNC id 9806
Location 5p13.3-p13.2      Physical location : 34.905.366 - 34.915.780
Synonym name
  • DNA repair exonuclease REC1
  • Rad1-like DNA damage checkpoint
  • cell cycle checkpoint protein Hrad1
  • Synonym symbol(s) HRAD1, REC1
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    ZFR 5p13.2 zinc finger RNA binding protein LOC391775 5 similar to Chromosome 1 open reading frame 37 PC4 5p13.3 activated RNA polymerase II transcription cofactor 4 NPR3 5p14-p13 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) FLJ14054 5p13.3 hypothetical protein FLJ14054 LOC389278 5 similar to 40S ribosomal protein S8 TARS 5p13.3-p13.2 threonyl-tRNA synthetase LOC389279 5 similar to RPE-spondin LOC391776 5 similar to Probable mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5) ADAMTS12 5q35 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 SALPR 5p15.1-p14 G-protein coupled receptor SALPR MATP 5p13.3 membrane associated transporter protein AMACR 5p13.3-p12 alpha-methylacyl-CoA racemase C1QTNF3 5p13-p12 C1q and tumor necrosis factor related protein 3 LOC389280 5 similar to SMA3 protein LOC389281 5 similar to bA110H4.2 (similar to membrane protein) RAI14 5p13.3-p13.2 retinoic acid induced 14 FLJ25439 5p13.3 hypothetical protein FLJ25439 RAD1 5p13.3-p13.2 RAD1 homolog (S. pombe) BRIX 5p13.3 BRIX LOC134218 5p13.3 hypothetical protein LOC134218 AGXT2 5p13 alanine-glyoxylate aminotransferase 2 PRLR 5p14-p13.3 prolactin receptor LOC389282 5 similar to RIKEN cDNA C230086A09 gene FLJ23577 5p13.2 hypothetical protein FLJ23577 IL7R 5p13 interleukin 7 receptor MGC26610 5p13.2 hypothetical protein MGC26610 FLJ34658 5p13.2 hypothetical protein FLJ34658 LOC167127 5p13.2 hypothetical protein LOC167127 DKFZp434H2226 5p13.2 hypothetical protein DKFZp434H2226 SKP2 5p13 S-phase kinase-associated protein 2 (p45) FLJ30596 5p13.2 hypothetical protein FLJ30596 FLJ25422 5p13.2 hypothetical protein FLJ25422 SLC1A3 5p13 solute carrier family 1 (glial high affinity glutamate transporter), member 3 LOC345513 5p13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) IDN3 5p13.2 IDN3 protein LOC391777 5 similar to ribosomal protein S4, X-linked FLJ13231 5p13.2 hypothetical protein FLJ13231 LOC389283 5 LOC389283 OFD1P1 5p13 oral-facial-digital syndrome 1, pseudogene 1 NUP155 5p13 nucleoporin 155kDa FLJ10233 5p13.2 hypothetical protein FLJ10233
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing - - - - 1998 9660799
    - splicing - - - - 1998 9660799
    - - 4683 - 282 - 2007 17583730
    - - 4765 - 282 - 2007 17583730
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • two regions containing potential leucine zipper motifs, functioning as a 3'-5' endonuclease
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae RAD17
    homolog to yeast S.pombe Rad
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • cell cycle G2 checkpoint control gene
  • also involved in DNA repair
  • play a role in DNA repair and cell cycle regulation
  • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with RAD9 and HUS1 for response to radiation exposure or incomplete DNA replication (RAD9-RAD1-HUS1 checkpoint complex stimulates flap endonuclease 1)
  • RAD17/ATR/RAD1, is the 9-1-1 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • by its N terminus with HUS1
  • by its C terminus with the C terminus of RAD9
  • DNA2 shows partial redundancy for the replication checkpoint with checkpoint initiators RAD9-RAD1-HUS1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS