| basic FUNCTION
| involved in the production of superoxide in neutrophils |
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putative regulator of mitogen-induced cytoskeletal changes essential for membrane ruffling and C-jun aminoterminal kinase JNK |
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regulator of actin filament at the plasma membrane to produce lamellipodia and membrane ruffles |
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key downstream target in Ras signaling |
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linking growth factor receptor to the activator of actin polymerization |
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activating JNK signaling pathway |
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shares with RAC1 the ability to interfere with cadherin-mediated adhesion  |
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both RAC1 and RAC3 are important for the development of the nervous system, wherein they play complementary roles during late stages of neuronal and brain development |
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induces cell rounding and prevents neuronal differentiation, in contrast to its close relative RAC1, which stimulates cell spreading and neuritogenesis |
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implicated in the regulation of cell migration and invasion in metastatic breast cancer cells |
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may have a specific function in neuronal cells |
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RHO family small GTPase that is associated with cytoskeletal rearrangement |
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role for neuronal RAC1 and RAC3 in dictating proper lymphoid organ development, suggesting the existence of lymphoid-extrinsic mechanisms linking neural defects to the loss of immune-competence |
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negative regulator of the process of autophagy |
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impact of its function on cancer cell survival through its modulation of autophagy |
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RAC1 and RAC3 GTPases participate in the normal development of hilar mossy cells, and indicate that they are involved in the regulation of the migration of the mossy cell precursor by preventing their arrival to the dorsal hilus |
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interplay between RAC3, hypoxia, and autophagy could be an important mechanism for tumor progression and a good target for a future anticancer therapy |
