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FLASH GENE
Symbol RABIF contributors: mct/npt - updated : 15-07-2008
HGNC name RAB interacting factor
HGNC id 9797
Location 1q32-q41      Physical location : 202.848.087 - 202.858.263
Synonym name
  • RAS-specific guamine-releasing factor 3
  • mammalian suppressor of SEC4
  • guanine nucleotide exchange factor MSS4
  • Synonym symbol(s) MSS4, SEC4GRF2, RASGFR3, RASGRF3
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 10.00 kb     2 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2452 13 123 - Stezl (2005)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     pancreas   highly
    Reproductivefemale systembreastmammary gland highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines pancreas cancer cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans t22d1.6
    Homologene
    FAMILY
  • specific for Sec4/Ypt/RAB family
  • RAS superfamily
  • GTP binding proteins
  • DSS4/MSS4 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • guanine nucleotide releasing (exchange) factor, involved in the regulation of intracellular vesicular transport
  • nucleotide exchange factor for exocytic Rab GTPases, acting as a novel integrin interacting protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with integrin (important for activation of matrix metalloproteinases (MMPs) and remodeling of secreted extracellular matrix (ECM) proteins)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS