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FLASH GENE
Symbol RABGGTB contributors: mct/npt - updated : 31-03-2009
HGNC name Rab geranylgeranyltransferase, beta subunit
HGNC id 9796
Location 1p31.1      Physical location : 76.251.885 - 76.260.764
Synonym name
  • type II protein geranyl-geranyltransferase subunit beta
  • Rab GG transferase beta
  • Synonym symbol(s) RGGTB, GGTB
    EC.number 2.5.1.60
    DNA
    TYPE functioning gene
    STRUCTURE 8.88 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1526 36 331 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Hearing/Equilibriumear   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    interspecies ortholog to rattus Rabggtb
    ortholog to murine Mbeta,Rabggtb
    ortholog to yeast S.pombe spbeta
    ortholog to C.elegans
    Homologene
    FAMILY
  • protein prenyltransferase subunit beta family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • regulator of vesicular transport steps in endocytic and secretory pathways
  • having a post-transcriptional regulation of its gene expression (Chinpaisal 1997)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • beta subunit forming a dimer with alpha subunit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with CHODL (Claessens 2008)
  • cell & other
    REGULATION
    activated by Rab escort proteins (REP1,CHML)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS