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FLASH GENE

Symbol

RAB9B

contributors: mct - updated : 29-09-2017

HGNC name	RAB9B, member RAS oncogene family
HGNC id	14090

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq22.1-q22.3      Physical location : 103.077.255 - 103.087.212
Synonym name	RAB9-like protein
Synonym symbol(s)	RAB9L, Rab-9L

DNA

TYPE	functioning gene
STRUCTURE	7.21 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016370 3 - 3799 NP_057454 22.6 201 - 2010 20048159

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

LipoP , Other

HOMOLOGY

interspecies	homolog to Drosophila EG:52C10.2
	homolog to C.elegans F16H9.1b

intraspecies

homolog to RAB9

Homologene

FAMILY	small GTPase superfamily
	Rab family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,granule

basic FUNCTION	involved in the transport of proteins between the endosomes and the trans Golgi network
	RAB9A and RAB9B, which are essential for alternative autophagy, but not conventional macroautophagy, severely suppressed mitophagy

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein	specific and strong interaction of HPS1, HPS4 with the GTP-bound form of the endosomal GTPase, RAB9A, RAB9B
	RAB9B can bind to SGSM1 probably in a similar manner as RAB9A

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS