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FLASH GENE
Symbol RAB8B contributors: mct/npt/pgu - updated : 30-01-2012
HGNC name RAB8B, member RAS oncogene family
HGNC id 30273
Location 15q22.2      Physical location : 63.481.727 - 63.559.971
Synonym name
  • RAB-8b protein
  • ras-related protein Rab-8B
  • Synonym symbol(s) FLJ38125
    DNA
    TYPE functioning gene
    STRUCTURE 78.25 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4877 - 207 - 2008 18772196
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a c-myc epitope tag at the extreme N terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text associated with the actin, intermediate filament, and microtubule cytoskeletal networks
    basic FUNCTION
  • may be involved in small GTPase mediated signal transduction, intracellular protein transport
  • may be involved in vesicular trafficking and neurotransmitter release
  • GTPase probably participating in intracellular trafficking events at the site of the adherens junction
  • participates in adherens junction dynamics in the testis
  • both RAB8A and RAB8B are important for ciliation in RPE cells
  • RAB8A and RAB8B are recruited by RAB11A after serum starvation for transport to the pericentriolar compartment
  • compensatory effect of RAB8A and RAB8B in apical transport, and neither RAB8A nor RAB8B are required for basolateral and/or dendritic transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • RAB8b/otoferlin complexes may thus play a role within the recycling of endosomes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with PEX5L (requires a guanine nucleotide but not prenylation for its interaction with PEX5L)
  • interacting with OTOF (interaction links otoferlin to this basolateral endocytic and secretory trafficking)
  • RAB3IL1 is a dual RAB-binding protein that could potentially link RAB3A and RAB11A/RAB11B and/or RAB8A/RAB8B and RAB11-mediated intracellular trafficking processes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS