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FLASH GENE
Symbol RAB6B contributors: mct/npt - updated : 27/09/2008
HGNC name RAB6B, member RAS oncogene family
HGNC id 14902
Location 3q22.2      Physical location : 133.543.081 - 133.614.691
Synonym name small GTPase RAB6B
DNA
TYPE functioning gene
STRUCTURE 71.61 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC344568 3q22.1 similar to proteasome (prosome, macropain) 26S subunit, ATPase 2; Proteasome (prosome, macropain) 26S subunit, ATPase LOC391577 3 similar to ribosomal protein L7 ACPP 3q21.3-q23 acid phosphatase, prostate LOC131039 3q22.1 similar to Saccharomyces cerevisiae Nip7p homolog RME8 3q22.1 RME8 protein FLJ12592 3q22.1 putative acyl-CoA dehydrogenase CCRL1 3q22 chemokine (C-C motif) receptor-like 1 UBE1DC1 3q22 ubiquitin-activating enzyme E1-domain containing 1 NPHP3 3q22.1 nephronophthisis 3 (adolescent) MGC3040 3q21 hypothetical protein MGC3040 BFSP2 3q21.2q22.3 beaded filament structural protein 2, phakinin MGC2848 3q22.1 hypothetical protein MGC2848 LOC391578 3 similar to MAF1 homolog; MAF1 homolog (yeast) H41 3q22.1 hypothetical protein H41 TOPBP1 3q22.1 topoisomerase (DNA) II binding protein LOC391579 3 similar to RIKEN cDNA 1300017J02 TF 3q21 transferrin PRO2086 3q22.1 PRO2086 protein APMCF1 3q22.1 PRO2086 protein RAB6B 3q22.2 RAB6B, member RAS oncogene family FLJ22173 3q22.1 hypothetical protein FLJ22173 SLCO2A1 3q21 solute carrier organic anion transporter family, member 2A1 RYK 3q22 RYK receptor-like tyrosine kinase AMOTL2 3q21-q22 angiomotin like 2 DKFZP566D193 3q22.1 DKFZP566D193 protein FLJ13386 3q22.1 hypothetical protein FLJ13386 FLJ33207 3q22.1 hypothetical protein FLJ33207 EPHB1 3q21-q23 EphB1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 5561 23.3 208 - Wanschers (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Hearing/Equilibriumear   highly
Nervousbrain   predominantly
 nerve   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousglia
cell lineage
cell lines neuroblastoma cell lines SK-N-SH
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
    • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text with BICD1 co-localize at the Golgi and vesicles that align along microtubules
    basic FUNCTION
  • small GTPase playing a potential specific role in retrograde membrane traffic
  • playing a regulatory role in the retrograde transport of cargo in neuronal cells, via its interaction with BICD1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6KIF1, other RAB6A effectors
  • with BICD1
  • DYNLRB1 specifically interacts with all three RAB6 isoforms and co-localises at the Golgi (Wanschers 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS