Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RAB5B contributors: mct/ - updated : 06-02-2019
HGNC name RAB5B, member RAS oncogene family
HGNC id 9784
Location 12q13.2      Physical location : 56.367.861 - 56.388.478
Synonym name ras-related protein Rab-5B
DNA
TYPE functioning gene
STRUCTURE 22.77 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC121129 12q13.13 similar to seven transmembrane helix receptor LOC390329 12 similar to seven transmembrane helix receptor LOC121130 12q13.13 similar to seven transmembrane helix receptor PSMB3P 12q12 proteasome (prosome, macropain) subunit, beta type, 3 pseudogene MGC17301 12q13.13 hypothetical protein MGC17301 ITGA7 12q13.3 integrin, alpha 7 GCN5L1 12q13-q14 GCN5 general control of amino-acid synthesis 5-like 1 (yeast) RDH5 12q13-q14 retinol dehydrogenase 5 (11-cis and 9-cis) CD63 12q12-q13 CD63 antigen (melanoma 1 antigen) GDF11 12q12 growth differentiation factor 11 CIP29 12q13.13 cytokine induced protein 29 kDa ORMDL2 12q12 ORM1-like 2 (S. cerevisiae) DNAJ 12q13.13 DnaJ protein MMP19 12q14 matrix metalloproteinase 19 PYM 12q13.13 PYM protein DGKA 12q13.3 diacylglycerol kinase, alpha 80kDa SILV 12q13-q14 silver homolog (mouse) CDK2 12q13.3 cyclin-dependent kinase 2 SUOX RAB5B 12q13 RAB5B, member RAS oncogene family ZNFN1A4 12q13 zinc finger protein, subfamily 1A, 4 (Eos) RPS26 12q14 ribosomal protein S26 ERBB3 12q13.3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) PA2G4 12q13 proliferation-associated 2G4, 38kDa RPL41 12q14 ribosomal protein L41 FLJ14451 12q13.13 hypothetical protein FLJ14451 MBC2 12q13.13 hypothetical protein FLJ14451 MLC1SA 12q13.13 hypothetical protein FLJ14451 MYL6 12q12 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle SMARCC2 12q13-q14 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 RNF41 12q13.13 ring finger protein 41 MGC2731 12q13.13 hypothetical protein MGC2731 SLC39A5 12q13.3 solute carrier family 39 (metal ion transporter), member 5 FLJ34236 12q13.13 hypothetical protein FLJ34236 FLJ32452 12q13.13 hypothetical protein FLJ32452
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3336 23.6 215 - 2009 19723633
6 - 5299 - 215 - 2009 19723633
5 - 5217 - 174 - 2009 19723633
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver   highly
Nervousbrain    
Reproductivefemale systemuterus   
 female systembreastmammary gland  
 female systemovary   
Skin/Tegumentskin    
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumskeletal  
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Rab5b
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • GTPase involved in endocytosis
  • involved in vesicular trafficking at the plasma membrane
  • regulatory role for RAB5A, RAB5B, RAB5C in not only the early endocytic pathway, but also the late endocytic pathway, of membrane trafficking in coordination with PI(3)K activity
  • selective association of RAB5A and RIN1 contributes to the dominance of RAB5A in EGFR trafficking, whereas RAB5B, RAB5C may have major functions unrelated to the EGFR degradation pathway
  • role of RAB5A, RAB5B, RAB5C as endosome organizer revealing the resilience mechanisms of the endocytic system
  • RAB5A, RAB5B, RAB5C are principal components of early endosome biogenesis
  • RAB5A, RAB5B, RAB5C selectively oversee the multiple signaling and trafficking events associated with the endocytic network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • interacting with LRRK2 (in conjunction with its interaction with RAB5B, LRRK2 plays an important role in synaptic function by modulating the endocytosis of synaptic vesicles)
  • small GTPase protein that regulates the motility and fusion of early endosomes, interacting with LRRK2 and co-regulating synaptic vesicle endocytosis
  • cell & other
    REGULATION
    Phosphorylated by LRRK2 (LRRK2 phosphorylates RAB5B at its Thr6 residue)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    led to spindle-shaped cells that displayed reduced formation of membrane ruffles
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS