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FLASH GENE
Symbol RAB4B contributors: SGE/npt - updated : 06-04-2010
HGNC name RAB4B, member RAS oncogene family
HGNC id 9782
Location 19q13.2      Physical location : 41.284.170 - 41.302.847
Synonym name
  • ras-related GTP-binding protein 4b
  • small GTP binding protein RAB4B
  • Synonym symbol(s) FLJ78649, MGC52123
    DNA
    TYPE functioning gene
    STRUCTURE 18.68 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1160 - 213 - He (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinecolon lowly
     intestinesmall intestine  lowly
     pancreas exocrine   moderately
    Lymphoid/Immunelymph node   highly
     spleen   lowly
     thymus   highly
    Reproductivefemale systemovary  highly
     female systembreastmammary gland predominantly
     male systemprostate  highly
     male systemtestis  lowly
    Respiratorylung   lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Rab F motifs and Rab SF regions
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to rattus Rab4b (99.5 pc)
    homolog to murine Rab4b (99.5 pc)
    homolog to Drosophila Rab4 (75 pc)
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
  • RAS oncogene family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    text lipid-anchor to the cytoplasmic side of the cell membrane
    basic FUNCTION
  • regulating vesicular trafficking pathways
  • important player in the control of SLC2A4 trafficking in adipocytes (difference in its expression in obese diabetic states could act as a compensatory effect to minimize the glucose transport defect in their adipocytes) (Kaddai 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular trafficking
    PATHWAY
    metabolism
    signaling
    a component
  • prenylated, methylated
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
    cell & other
    REGULATION
    induced by the same regulatory machinery known to be essential for the expression of MHC class II genes
    Other regulated by a typical MHC class II-like enhancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Kawasaki disease
    Variant & Polymorphism SNP
  • rs2233152 near MIA and RAB4B highly associated to Kawasaki disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS