Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RAB3IP contributors: npt/mct - updated : 17-06-2015
HGNC name RAB3A interacting protein (rabin3)
HGNC id 16508
Location 12q15      Physical location : 70.132.630 - 70.216.982
Synonym name
  • RAS-like GTPase interactor homolog
  • SSX2 interacting protein
  • RAB8A-specific GEF
  • Synonym symbol(s) RABIN3, FLJ14660, FLJ22548, MGC71495, RABIN8
    DNA
    TYPE functioning gene
    STRUCTURE 84.80 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DYRK2 12q14.3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 LOC341333 12q14.3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) IFNG 12q14-q15 interferon, gamma IL26 12q15 interleukin 26 IL22 12q15 interleukin 22 MDM1 12q14.3 nuclear protein double minute 1 LOC160410 12q14.3 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene LOC387867 12 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) RAP1B 12q14 RAP1B, member of RAS oncogene family LOC246723 12q14 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene NUP107 12q14.3 nuclear pore complex protein SLC35E3 12q15 solute carrier family 35, member E2 PRO2268 12q14.3 hypothetical protein PRO2268 MDM2 12q14.3-q15 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) MGC5370 12q14.3 hypothetical protein MGC5370 CPM 12q15 carboxypeptidase M CPSF6 12q13.2 cleavage and polyadenylation specific factor 6, 68kDa LYZ 12q14-q15 lysozyme (renal amyloidosis) GAS41 12q13-q15 lysozyme (renal amyloidosis) FRS2 12q15 fibroblast growth factor receptor substrate 2 CCT2 12q15 chaperonin containing TCP1, subunit 2 (beta) LOC387868 12 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 VMD2L3 12q14.2-q15 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 MGC13168 12q14.3 hypothetical protein MGC13168 RAB3IP 12q13-q15 RAB3A interacting protein (rabin3) FLJ25056 12q14.3 hypothetical protein FLJ25056 CNOT2 12q13.2 CCR4-NOT transcription complex, subunit 2 KCNMB4 12q14.1-q15 potassium large conductance calcium-activated channel, subfamily M, beta member 4 LOC390342 12 similar to Gag-Pro-Pol-Env protein PTPRB 12q15 protein tyrosine phosphatase, receptor type, B PTPRR 12q13.2-q13.3 protein tyrosine phosphatase, receptor type, R TM4SF3 12q14.1-q21.1 transmembrane 4 superfamily member 3 GPR49 12q22-q23 G protein-coupled receptor 49 MGC23401 12q15 hypothetical protein MGC23401 DKFZP564I0422 12q15 hypothetical protein DKFZp564I0422 FLJ10936 12q15 hypothetical protein FLJ10936 RAB21 12q13.3 RAB21, member RAS oncogene family
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 9517 51 460 - 2002 12007189
  • RAB3IP-A1
  • 11 - 9651 - 476 - 2002 12007189
  • RAB3IP-A2
  • 10 - 9417 - 395 - 2002 12007189
  • RAB3IP-B1
  • 10 - 9551 - 411 - 2002 12007189
    RAB3IP-B2
    - - - - 304 - 2002 12007189
    - - - - 320 - 2002 12007189
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, thymus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one ER retention motif
  • one coiled-coil domain
  • one nuclear localization signal (NLS)
  • the GEF domain RAB3IP display the minimal targeting machinery for recruiting their cognate RABs (RAB1A and RAB8A, respectively) to the mitochondrial membrane
  • HOMOLOGY
    interspecies homolog to rattus Rabin3
    Homologene
    FAMILY
  • SEC2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text localized to the cortical actin (Hattula 2002)
    basic FUNCTION
  • involved in mediating polarized membrane transport (Hattula 2005)
  • having exchange activity on RAB8A and RAB8B but not on RAB3A (Hattula 2002)
  • Rab8-specific activator that is connected to processes that mediate polarized membrane traffic to dynamic cell surface structures (Hattula 2002)
  • is a direct phospho-substrate of ERK1/2 in response to EGF signaling, and ERK1/2 activate RAB3IP to regulate vesicular trafficking to the plasma membrane in response to extracellular signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SSX2
  • bind RAB8A and function as nucleotide exchange factors for Rab8 but not for RAB3A and RAB5 (Hattula 2005)
  • ASAP1 serves as a scaffold that brings together the proteins necessary for transport to the cilia including the GTP-binding protein ARF4 and the two G proteins of the Rab family--RAB11A and RAB8A--linked by the RAB8A guanine nucleotide exchange factor RAB3IP
  • components of the vesicular transport machinery, the GEF RAB3IP and the GTPase RAB8A, are interacting partners of CEP164
  • RAB11FIP3 coordinates the interactions of ASAP1 and RAB11A with RAB3IP
  • RAB11FIP3 acts synergistically with ASAP1 to direct RAB3IP in ciliary receptor targeting
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS