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FLASH GENE
Symbol RAB3IL1 contributors: mct - updated : 02-02-2017
HGNC name RAB3A interacting protein (rabin3)-like 1
HGNC id 9780
Location 11q12.2      Physical location : 61.664.773 - 61.684.997
Synonym name
  • Rabin3-like 1
  • guanine nucleotide exchange factor for Rab3A
  • RIM (Rab3A interacting molecule)
  • Synonym symbol(s) GRAB, RIM
    DNA
    TYPE functioning gene
    STRUCTURE 49.02 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DKFZP586B1621 11q12.3 DKFZP586B1621 protein MGC20446 11q12.3 hypothetical protein MGC20446 HSPC196 11q12.3 hypothetical protein HSPC196 MGC:13379 11q13.1 HSPC244 FLJ12529 11q12.3 pre-mRNA cleavage factor I, 59 kDa subunit FLJ20487 11q12.3 hypothetical protein FLJ20487 FLJ32771 11q12.3 IIIG9 protein SYT7 11q12-q13.1 synaptotagmin VII LOC390205 11 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 RPLP0P2 11cen-q12 ribosomal protein, large, P0 pseudogene 2 C11orf11 11q13.1 chromosome 11 open reading frame 11 C11orf9 11q12-q13.1 chromosome 11 open reading frame 9 C11orf10 11q12-q13.1 chromosome 11 open reading frame 10 FEN1 11q13.1 flap structure-specific endonuclease 1 FADS1 11q12.2-q13.1 fatty acid desaturase 1 FADS2 11q12-q13.1 fatty acid desaturase 2 FADS3 11q12-q13.1 fatty acid desaturase 3 RAB3IL1 11q12-q13.1 RAB3A interacting protein (rabin3)-like 1 VMD2 11q12-q13.1 vitelliform macular dystrophy (Best disease, bestrophin) FTH1 11q13.1 ferritin, heavy polypeptide 1 LOC387774 11 LOC387774 LOC390206 11 similar to 40S ribosomal protein S2 INCENP 11q12-q13 inner centromere protein antigens 135/155kDa LOC283236 11q12.3 similar to eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein SCGB1D1 11q13 secretoglobin, family 1D, member 1 SCGB2A1 11q13 secretoglobin, family 2A, member 1 SCGB1D2 11q13 secretoglobin, family 1D, member 2 SCGB2A2 11q13 secretoglobin, family 2A, member 2 ASRGL1 11q12.3 asparaginase like 1 SCGB1A1 11q12.2-q13.1 secretoglobin, family 1A, member 1 (uteroglobin)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2392 42 382 - 2001 11516400
    9 - 2149 - 356 - 2001 11516400
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • SEC2 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • GTPase activity
  • regulates depolarization-induced release of dopamine from PC12 cells
  • RAB3IL1 and its binding partner UNC13B, and the subsequent gating of vesicle fusion by activation of the Ca2+ channels, are implicated in the docking of vesicles at the transmitter release site, a process of neurosecretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a dual RAB-binding protein that could potentially link RAB3A and RAB11A/RAB11B and/or RAB8A/RAB8B and RAB11-mediated intracellular trafficking processes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS