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Symbol RAB3IL1 contributors: mct - updated : 02-02-2017
HGNC name RAB3A interacting protein (rabin3)-like 1
HGNC id 9780
Location 11q12.2      Physical location : 61.664.773 - 61.684.997
Synonym name
  • Rabin3-like 1
  • guanine nucleotide exchange factor for Rab3A
  • RIM (Rab3A interacting molecule)
  • Synonym symbol(s) GRAB, RIM
    DNA
    TYPE functioning gene
    STRUCTURE 49.02 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2392 42 382 - 2001 11516400
    9 - 2149 - 356 - 2001 11516400
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • SEC2 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • GTPase activity
  • regulates depolarization-induced release of dopamine from PC12 cells
  • RAB3IL1 and its binding partner UNC13B, and the subsequent gating of vesicle fusion by activation of the Ca2+ channels, are implicated in the docking of vesicles at the transmitter release site, a process of neurosecretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a dual RAB-binding protein that could potentially link RAB3A and RAB11A/RAB11B and/or RAB8A/RAB8B and RAB11-mediated intracellular trafficking processes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS