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FLASH GENE
Symbol RAB3D contributors: mct/ - updated : 07-12-2011
HGNC name RAB3D, member RAS oncogene family
HGNC id 9779
Location 19p13.2      Physical location : 11.432.722 - 11.450.344
Synonym name
  • glioblastoma overexpressed
  • Rab3D upregulated with myeloid differentiation
  • ras-related protein Rab-3D
  • Synonym symbol(s) GOV, RAD3D, D2-2, RAB16
    DNA
    TYPE functioning gene
    STRUCTURE 17.62 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4290 - 219 - 1999 10023084
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
     stomach   highly
    Endocrineadrenal glandcortex  highly
     pancreas   highly
     thyroid   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte
    Skeletonosteoclast Homo sapiens
    cell lineage
    cell lines constitutively and lowly expressed in all hematopoietic cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain highly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated LipoP , Other
    HOMOLOGY
    interspecies homolog to murine Rab3d
    homolog to Drosophila rab3
    homolog to C.elegans rab-3
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab3 subfamily (Rab3A/B/C/D) of small exocytotic GTPases
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • DYNLT1 and RAB3D intimately associate with the dynein motor complex and microtubules in osteoclasts
  • basic FUNCTION
  • involved in regulated exocytosis
  • RAB3-induced modifications to primed vesicles causes a transient increase in the transduction efficacy of synaptic action potential trains and optimizes the encoding of synaptic information at an intermediate spike frequency range
  • implication of myosin Va and RAB3D in the maturation of SGs (secretory granules) where they participate in overlapping but not identical tasks
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , exocytosis transport
    text vesicle transport; hemocyte development
    PATHWAY
    metabolism
    signaling
    a component
  • components of the RAB3D-trafficking pathway contribute to the maintenance of osteoclastic resorptive function
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • interaction between RAB3D and PIGR implicated in trafficking through regulated secretory vesicles in lacrimal gland acinar cells
  • DYNLT1 is a RAB3D-interacting partner (binds specifically to RAB3D in a GTP-dependent manner and co-occupies RAB3D-bearing vesicles in bone-resorbing osteoclasts)
  • cell & other
    REGULATION
    induced by BHLHA15 transcription factor
    Other activated in myeloid differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS