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FLASH GENE
Symbol RAB3B contributors: mct - updated : 24-02-2013
HGNC name RAB3B, member RAS oncogene family
HGNC id 9778
Corresponding disease
AOMS3 abdominal obesity-metabolic syndrome-3
Location 1p32.3      Physical location : 52.373.627 - 52.456.436
Synonym name brain antigen RAB3B
DNA
TYPE functioning gene
STRUCTURE 71.51 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1565 - 219 - 2003 12901864
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Endocrinepancreas   highly
 thyroid    
Nervousbrainlimbic systemhippocampus highly Homo sapiens
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Rab3b
ortholog to rattus rab3b
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm,cytosolic
    text localize to tight junction in polarized epithelial cells and cytoplasmic vesicular structures in non-polarized fibroblasts
    basic FUNCTION
  • GTPase, involved in calcium Ca2+ regulated exocytosis
  • may contribute to epithelial polarization
  • RAB3-induced modifications to primed vesicles causes a transient increase in the transduction efficacy of synaptic action potential trains and optimizes the encoding of synaptic information at an intermediate spike frequency range
  • control the regulated exocytosis in neuronal/secretory cells
  • low molecular weight GTP-binding protein that has been implicated in the regulation of exocytosis
  • involved in the regulation of pituitary hormone secretion
  • having an additional and unexpected function in the localization of presynaptic proteins to active zones
  • may improves dopamine handling and storage capacity at presynaptic terminals, and confers protection to vulnerable dopaminergic neurons
  • function as a regulator of synaptic vesicle dynamics in mammalian neurons
  • RAB3B/RAB3C was indicated to be colocalized with MHC class I molecules at perinuclear tubular structure
  • with RAB27B, probably in concert with RAB3A and RAB3C, is involved in synaptic vesicles exocytosis
  • RAB3B/RAB3C-positive recycling vesicles are involved in and may constitute one of the recycling compartments in exogenous antigen cross-presentation
  • play two distinct stimulating roles for large dense-core vesicles fusion in embryonic chromaffin cells, by facilitating vesicle biogenesis and stabilizing the primed vesicle state
  • key player in the presynaptic machinery that modulates long-term plasticity in inhibitory synapses
  • required for long-term presynaptic plasticity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • interacting with calmodulin
  • interacting with RAB13 (direct the cell-surface transport of LDLR and Claudin-1, respectively)
  • GAS8 is a RABB-binding protein
  • interacts with the RIMS1 and RIMS2 as effector proteins in a GTP-dependent manner
  • NKX3-1, AR, and FOXA1 promote prostate cancer cell survival by directly upregulating RAB3B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AOMS3
    Susceptibility
    Variant & Polymorphism
    Candidate gene intriguing neuroprotective candidate that may modify disease progression potentially by restoring neurotransmission and synaptic vesicle transport
    Marker
    Therapy target
    ANIMAL & CELL MODELS