SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
| intracellular,cytoplasm,cytosolic
|
basic FUNCTION
| involved in melanosomal transport and docking |
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involved in the proper sorting of TYRP1 |
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regulating intracellular vesicle trafficking, and early vesicle transport relating to the endoplasmic reticulum |
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might be required for the normal trafficking of TYRP1 from the trans-Golgi network (TGN) to the maturing melanosome |
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with RAB32 may play a redundant role in regulating transport of tyrosinase from the TGN to melanosomes |
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may play a role in the development of dense granules in the megakaryocytes and platelets |
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RAB27A, RAB38 and RAB32 function in melanosome maturation or trafficking in melanocyte |
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potentially playing an indispensible role in maintaining lamellar body morphology and surfactant homeostasis in alveolar type II (ATII) pneumocytes |
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RAB38 and RAB32 are the specific factors that direct the ubiquitous machinery to mediate transport from early endosomes to maturing lysosome-related organelles |
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RAB38 and RAB32 operate together with the ubiquitous transport machinery in pathways from early endosomal domains toward maturing melanosomes |
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regulates intracellular vesicle trafficking |
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RAB32 and its closest homologue RAB38 are known to organize the trans-Golgi network and transport of key enzymes in melanogenesis |
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dramatic depletion of VAMP7-containing recycling tubules in cells lacking HPS4 suggests that RAB38 and/or RAB32 play an important role in recruiting effectors for cargo selection, tubule formation, and/or tubule release |