Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RAB36 contributors: mct - updated : 10-10-2012
HGNC name RAB36, member RAS oncogene family
HGNC id 9775
Location 22q11.22      Physical location : 23.487.512 - 23.506.531
Synonym name small GTP-binding protein Rab36
EC.number 3.6.5.1/ 3.6.5.2/ 3.6.5.3/ 3.6.5.4
DNA
TYPE functioning gene
STRUCTURE 19.02 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen -D22S556 - IGLC2 - D22S303 - GNAZ - D22S257 - BCR - D22S301 - IGLL1 - MMP11 - D22S345 - D22S156 - D22S621 - qter
Authors Mori (99)
Physical map
RTDR1 22q11.2 rhabdoid tumor deletion region gene 1 GNAZ 22q11.22 guanine nucleotide binding protein (G protein), alpha z polypeptide RAB36 22q11.2 RAB36, member RAS oncogene family BCR 22q11.23 breakpoint cluster region FBXW3 22q11 F-box and WD-40 domain protein 3 LOC343851 22q11.23 similar to hypothetical protein FLJ31547
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3822 36.3 333 - 1999 9920784
containing a longer 3 prime noncodong sequence
- - - 2200 - - - 1999 9920784
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three phosphate/magnesium-binding motifs
  • three guanine-binding motifs
  • a tyrosine kinase phosphorylation site
  • a C terminal isoprenylation signal
  • HOMOLOGY
    interspecies homolog to murine Rab36
    homolog to C.elegans f10g8.6
    intraspecies homolog to rab13
    homolog to RAB34
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • GTPase, involved in vesicular trafficking associated with intra-Golgi transport
  • may regulate the spatial distribution of late endosomes and lysosomes through a similar mechanism to RAB34
  • mediates retrograde melanosome transport in melanocytes through interaction with RILP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide, other,
  • Mg2+
  • GTP
  • phosphate
  • protein
  • membrane-associated SGSM1 co-localizes with RAB36, and expression of SGSM1, decreases the amount of membrane-associated RAB36 protein
  • SGSM1 can act as a RAB36 GAP in cells and suggest that it links RAB9A function to RAB36 function in the endosomal system
  • RAB35 functions as a master RAB that determines the intracellular localization of MICALL1, which in turn functions as a scaffold for RAB8A, RAB13, and RAB36
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS