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FLASH GENE

Symbol

RAB34

contributors: mct - updated : 02-10-2012

HGNC name	RAB34, member RAS oncogene family
HGNC id	16519

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q11.2      Physical location : 27.041.298 - 27.045.286
Synonym name	Ras-related protein Rah
Synonym symbol(s)	RAH, RAB39

DNA

TYPE	functioning gene
STRUCTURE	3.99 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031934 10 - 1785 NP_114140 28.9 259 - 2003 12684051 NM_001256278 9 - 1162 NP_001243207 - 259 - 2003 12684051 NM_001142624 11 - 1309 NP_001136096 - 308 - 2003 12684051 NM_001144943 11 - 1333 NP_001138415 - 316 - 2003 12684051 NM_001142625 10 - 1118 NP_001136097 - 268 - 2003 12684051 NM_001256276 10 - 1401 NP_001243205 - 237 - 2003 12684051 NM_001256277 11 - 1467 NP_001243206 - 259 - 2003 12684051 NM_001144942 10 - 1761 NP_001138414 - 251 - 2003 12684051

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver         Endocrine pancreas       highly Nervous brain         Reproductive male system prostate     highly Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

LipoP , Other

HOMOLOGY

intraspecies

homolog to RAB36

Homologene

FAMILY	small GTPase superfamily
	Rab family

CATEGORY

protooncogene , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	involved in vesicular traffic
	Golgi-localized RAB34 has been implicated in repositioning lysosomes and activation of macropinocytosis
	novel member of the secretory pathway acting at the Golgi
	RAB34 and its effector UNC13B constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia
	Golgi-associated Rab protein that regulates lysosomal positioning through interaction with RILP

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	protein transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein	UNC13B serves as an effector of RAB34, mediating lysosome-Golgi trafficking
	UNC13B and RAB34 interact at the Golgi via the munc13 homology domain 2 (MHD2)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS