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FLASH GENE
Symbol RAB33A contributors: mct - updated : 26-08-2013
HGNC name RAB33A, member RAS oncogene family
HGNC id 9773
Location Xq26.1      Physical location : 129.305.772 - 129.318.843
Synonym name small GTP binding protein S10
Synonym symbol(s) S10, RABS10, MGC1488
DNA
TYPE functioning gene
STRUCTURE 13.07 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure regulated by DNA methylation of a specific promoter region proximal to the transcription initiation site
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1128 - 237 - 2012 22972995
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunetonsils    
Nervousbrain    
Visualeye   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
Skin/Tegumentmelanocyte
cell lineage lymphoid and monocytic lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
G1 through G5 conserved regions
HOMOLOGY
interspecies homolog to murine Rab33a
homolog to C.elegans C39F7.4
Homologene
FAMILY
  • RAB subfamily of small GTPases
  • RAS oncogene family
  • CATEGORY enzyme , protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • preferentially localized to the Golgi apparatus and to synaptophysin-positive vesicles that are transported along the growing axon
  • basic FUNCTION
  • may be involved in vesicle transport
  • may have an important role in disorders involving X-chromosome-linked genes associated with vesicular transport
  • T cell regulatory molecule in tuberculosis, suggesting its involvement in disease processes
  • modulates autophagosome formation through interaction with ATG16L1
  • participates potentially in axon outgrowth by mediating anterograde axonal transport of synaptophysin-positive vesicles and their concomitant fusion at the growth cones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicular transport and membrane fusion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • RAB33B (and RAB33A) specifically interacts with ATG16L1, an essential factor in isolation membrane formation, in a guanosine triphosphate-dependent manner
  • ATG16L1 interacts with the small GTPase RAB33A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS