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FLASH GENE
Symbol RAB27B contributors: mct - updated : 05-02-2015
HGNC name RAB27B, member RAS oncogene family
HGNC id 9767
Location 18q21.2      Physical location : 52.495.839 - 52.557.207
Synonym name
  • RAS-related gene from megakaryocyte, B
  • ras-related protein Rab-27B
  • Synonym symbol(s) C25KG
    DNA
    TYPE functioning gene
    STRUCTURE 61.37 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1365 - 218 - 2003 12907454
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach     Homo sapiensAdult
    Endocrineneuroendocrinepituitary    Homo sapiens
     pancreas     Homo sapiens
     thyroid     Homo sapiens
    Reproductivemale systemmale genital tractseminiferous tubule   Homo sapiens
    Skin/Tegumentskin     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialbarrier liningendometrium   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte Homo sapiens
    Blood/Hematopoieticplatelet Homo sapiens
    Digestivegastric Homo sapiensAdult
    not specificmast cell Homo sapiens
    Reproductiveepithelial cell Homo sapiens
    Skin/Tegumentkeratinocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GTP binding site motif A (P-loop)
  • two consensus C terminal cysteine residues to be anchored to membranes
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to Rattus Rab27b (93.6pc)
    homolog to murine Rab27b (94.5pc)
    intraspecies paralog to RAB27A
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY enzyme , immunity/defense , regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nuclear envelope
    text
  • membrane bound
  • mainly present in a perinuclear distribution
  • basic FUNCTION
  • small GTPase, key effector of cytotoxic granule exocytosis, vesicle transport and organelles dynamics, targeting transport and fusion of vesicles within their appropriate membrane acceptors
  • may be involved in targeting uroplakins to urothelial apical membranes
  • is involved in pituitary hormone secretion
  • may coordinate proplatelet formation with granule transport, possibly by recruiting specific effector pathways
  • functions in the multivesicular endosome docking at the plasma membrane and secretion
  • RAB27A and RAB27B control different steps of the exosome secretion pathway
  • RAB27A, RAB27B play independent roles in neutrophil exocytosis (PMID;
  • may play a role in stimulation-associated membrane recruitment and gastric acid secretion
  • with RAB3A, probably in concert with RAB3B and RAB3C, is involved in synaptic vesicles exocytosis
  • participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release
  • role in megakaryocytic lineage cells, and furthermore it is possible that RAB27B-mediated control of KIT expression might lead to the fine regulation of hematopoiesis in the bone marrow
  • RAB27A and RAB27B regulate exocytosis of multivesicular endosomes
  • RAB27B and EXPH5 have putative roles in intracellular vesicle trafficking
  • role as a key regulator of dense granule secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • GTP binding
  • protein
  • binding SYTL4 and MYRIP
  • interacting with SYTL2, and SYTL1
  • RAB27A and RAB27B are involved in the stimulation-dependent TNFSF11 release pathway in osteoblastic cells
  • negatively regulates the cell surface expression of KIT via secretion of KITLG and ligation of KITLG leads to the endolysosomal degradation system of KITc
  • TBC1D10B can serve as a potential physiological GAP for RAB27B and thereby participate in the regulation of exocytosis in pancreatic acinar cells
  • cell & other
    REGULATION
    Other post-translationally acetylated, methylated or prenylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer coincides with lymph node metastasis and acquisition of a poor prognostic phenotype
    tumoral     --low  
    in advanced prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS