SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,nuclear envelope
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text
| membrane bound |
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mainly present in a perinuclear distribution |
basic FUNCTION
| small GTPase, key effector of cytotoxic granule exocytosis, vesicle transport and organelles dynamics, targeting transport and fusion of vesicles within their appropriate membrane acceptors |
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may be involved in targeting uroplakins to urothelial apical membranes |
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is involved in pituitary hormone secretion |
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may coordinate proplatelet formation with granule transport, possibly by recruiting specific effector pathways |
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functions in the multivesicular endosome docking at the plasma membrane and secretion |
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RAB27A and RAB27B control different steps of the exosome secretion pathway |
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RAB27A, RAB27B play independent roles in neutrophil exocytosis (PMID; |
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may play a role in stimulation-associated membrane recruitment and gastric acid secretion |
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with RAB3A, probably in concert with RAB3B and RAB3C, is involved in synaptic vesicles exocytosis |
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participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release |
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role in megakaryocytic lineage cells, and furthermore it is possible that RAB27B-mediated control of KIT expression might lead to the fine regulation of hematopoiesis in the bone marrow |
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RAB27A and RAB27B regulate exocytosis of multivesicular endosomes |
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RAB27B and EXPH5 have putative roles in intracellular vesicle trafficking |
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role as a key regulator of dense granule secretion |