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FLASH GENE
Symbol RAB26 contributors: mct - updated : 24-03-2015
HGNC name RAB26, member RAS oncogene family
HGNC id 14259
Location 16p13.3      Physical location : 2.198.650 - 2.204.140
Synonym name Ras-related oncogene protein
Synonym symbol(s) V46133
DNA
TYPE functioning gene
STRUCTURE 5.49 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
DKFZP566J2046 16p13.3 hypothetical protein DKFZp566J2046 MGC35212 16p13.3 hypothetical protein MGC35212 LOC342460 16p13.3 similar to c439A6.1 (novel protein similar to heparan sulfate (glucosamine) 3-O-sulfotransferases) SEPX1 16p13.3 selenoprotein X, 1 RPL3L 16p13.3 ribosomal protein L3-like NDUFB10 16p13.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa RPS2 16p13.3 ribosomal protein S2 RNF151 16p13.3 ring finger protein 151 TBL3 16p13.3 transducin (beta)-like 3 NOXO1 16p13.3 NADPH oxidase organizer 1 GFER 16p13.3-p13.12 growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) SYNGR3 16p13 synaptogyrin 3 LOC90850 16p13.3 hypothetical protein LOC90850 SLC9A3R2 16p13.3 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2 NTHL1 16p13.3p13.2 nth endonuclease III-like 1 (E. coli) TSC2 16p13.3 tuberous sclerosis 2 PKD1 16p13.3 polycystic kidney disease 1 (autosomal dominant) RFWD1 16p13.3 ring finger and WD repeat domain 1 RAB26 16p13.3 RAB26, member RAS oncogene family CASKIN1 16p13.11 CASK interacting protein 1 GBL 16p13.3 G protein beta subunit-like MGC21830 16p13.3 hypothetical protein MGC21830 LOC388203 16 LOC388203 LOC283871 16p13.3 hypothetical protein LOC283871 E4F1 16p13.3 E4F transcription factor 1 DNASE1L2 16p13.3 deoxyribonuclease I-like 2 DCI 16p13.3 dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase) RNPS1 16p13.3 RNA binding protein S1, serine-rich domain LOC388204 16 LOC388204 ABCA3 16p13.3 ATP-binding cassette, sub-family A (ABC1), member 3 LOC390669 16 similar to ATP-binding cassette transporter ABCA3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1641 27.8 256 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 pancreas exocrine   moderately
Nervousbrain   highly
Reproductivemale systemprostate  predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP
HOMOLOGY
interspecies homolog to rattus Rab26 (93.7 pc)
homolog to murine Rab26 (87.5 pc)
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    text
  • intrinsic to plasma membrane
  • lipid-anchor, cytoplasmic side
  • basic FUNCTION
  • participating in exocrine secretion
  • regulating the secretion of acinar granules in the parotid gland
  • involved in regulation of exocytosis
  • important function of RAB26 in coordinating plasma membrane protein transport
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • exocrine system development
  • PATHWAY
    metabolism
    signaling signal transduction
  • small GTPase mediated signal transduction
  • a component
  • prenylation
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • ATP
  • protein
  • directly and activation-dependently interacted with ADRA2B, specifically the third intracellular loop
  • cell & other
    REGULATION
    induced by BHLHA15 transcription factor (Tian 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS