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FLASH GENE
Symbol RAB24 contributors: mct - updated : 21-02-2012
HGNC name RAB24, member RAS oncogene family
HGNC id 9765
Location 5q35.3      Physical location : 176.728.199 - 176.730.744
Synonym name Ras-related protein Rab-24
DNA
TYPE functioning gene
STRUCTURE 2.55 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1612 23 203 - 2002 12323076
9 - 1526 23 203 - 2002 12323076
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart    
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemprostate  highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Rab24
homolog to Drosophila rab2
homolog to C.elegans F11A5.5
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    text
  • SRPX was co-localized with RAB24 on punctuated structures during autophagy
  • basic FUNCTION
  • role in degradation of misfolded cellular proteins or trafficking of proteins to the nuclear envelope
  • differs from other Rab proteins in that it has a low intrinsic GTPase activity and is not efficiently prenylated
  • required, or involved at various stages of autophagosomal genesis and maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • interaction between human RAB24 and two proteins, cyclophilin A (PPIA) and gamma-aminobutyric acid type A receptor-associated protein (GABARAP)
  • RAB3A, RAB24, and septin 4 bind to the N-terminal domain of SNAP29
  • SRPX could associate with RAB24 and the association with RAB24 was enhanced during autophagy
  • cell & other
    REGULATION
    Other tyrosine phosphorylated, which could potentially influence RAB24 targeting and interactions with effector protein complexes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS