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FLASH GENE

Symbol

RAB24

contributors: mct - updated : 21-02-2012

HGNC name	RAB24, member RAS oncogene family
HGNC id	9765

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q35.3      Physical location : 176.728.199 - 176.730.744
Synonym name	Ras-related protein Rab-24

DNA

TYPE	functioning gene
STRUCTURE	2.55 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001031677 8 - 1612 NP_001026847 23 203 - 2002 12323076 NM_130781 9 - 1526 NP_570137 23 203 - 2002 12323076

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart         Endocrine pancreas       highly Nervous brain       highly Reproductive male system prostate     highly Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to murine Rab24
	homolog to Drosophila rab2
	homolog to C.elegans F11A5.5

Homologene

FAMILY	small GTPase superfamily
	Rab family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic
text	SRPX was co-localized with RAB24 on punctuated structures during autophagy

basic FUNCTION	role in degradation of misfolded cellular proteins or trafficking of proteins to the nuclear envelope
	differs from other Rab proteins in that it has a low intrinsic GTPase activity and is not efficiently prenylated
	required, or involved at various stages of autophagosomal genesis and maturation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein	interaction between human RAB24 and two proteins, cyclophilin A (PPIA) and gamma-aminobutyric acid type A receptor-associated protein (GABARAP)
	RAB3A, RAB24, and septin 4 bind to the N-terminal domain of SNAP29
	SRPX could associate with RAB24 and the association with RAB24 was enhanced during autophagy

cell & other

REGULATION

Other	tyrosine phosphorylated, which could potentially influence RAB24 targeting and interactions with effector protein complexes

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS