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FLASH GENE
Symbol RAB23 contributors: mct/pgu - updated : 28-08-2017
HGNC name RAB23, member RAS oncogene family
HGNC id 14263
Corresponding disease
ACPS2 acrocephalosyndactyly type 2
Location 6p12.1      Physical location : 57.053.590 - 57.087.078
Synonym name
  • RAB family small GTP binding protein RAB 23
  • Ras-related protein Rab-23
  • Synonym symbol(s) HSPC137, MGC8900, DKFZp781H0695
    DNA
    TYPE functioning gene
    STRUCTURE 35.32 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GCLC 6p12 glutamate-cysteine ligase, catalytic subunit LOC391932 6 similar to bA345L23.2 (novel protein with BTB/POZ (broad complex Tramtrack bric-a-brac/Pox virus and zinc finger) domain) LRRC1 6p12.1 leucine-rich repeat-containing 1 C6orf142 6p12.2-p12.1 chromosome 6 open reading frame 142 TINAG 6p12-p11.2 tubulointerstitial nephritis antigen CLNS1B 6p12 chloride channel, nucleotide-sensitive, 1B LOC391933 6 similar to Transforming protein p21b (K-Ras 2B) (Ki-Ras) (c-K-ras) LOC221344 6p12.1 hypothetical LOC221344 LOC389399 6 LOC389399 C6orf143 6p12.1 chromosome 6 open reading frame 143 HCRTR2 6p11-q11 hypocretin (orexin) receptor 2 LOC389400 6 similar to IVFI9356 HMGCLL1 6p12.1 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 LOC391934 6 similar to nitrogen fixation cluster-like BMP5 6p11.1 bone morphogenetic protein 5 COL21A1 6p12.3-p11.2 collagen, type XXI, alpha 1 LOC221341 6p12.1 similar to RCC1-like BPAG1 6p12-p11 bullous pemphigoid antigen 1, 230/240kDa C6orf65 6p12.1 chromosome 6 open reading frame 65 MRPL30P1 6p12.1 chromosome 6 open reading frame 65 KIAA1586 6p12.1 KIAA1586 ZNF451 6p12.1 zinc finger protein 451 BAG2 6p12.3-p11.2 BCL2-associated athanogene 2 RAB23 6p11.2-p12.3 RAB23, member RAS oncogene family PRIM2A 6p12-p11.1 primase, polypeptide 2A, 58kDa LOC391935 6 similar to glyceraldehyde 3-phosphate dehydrogenase LOC346245 6p12.1 similar to Chromatin assembly factor 1 subunit C (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-Ip48) (Retinoblastoma binding protein p48) (Retinoblastoma-binding protein 4) (RBBP-4) (MSI1 pr LOC389401 6 similar to SMA3 protein LOC391936 6 similar to glyceraldehyde 3-phosphate dehydrogenase LOC389402 6 similar to Chromatin assembly factor 1 subunit C (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-Ip48) (Retinoblastoma binding protein p48) (Retinoblastoma-binding protein 4) (RBBP-4) (MSI1 pr
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2623 26.7 237 - 2003 14617350
    7 - 3037 26.7 237 - 2003 14617350
    7 - 4368 - 237 - 2003 14617350
    7 - 4540 - 237 - 2003 14617350
    7 - 4367 - 237 - 2003 14617350
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
    Nervousbrain    
     spinal cord    
    Reproductivefemale systemuterus  highly
    Urinarykidneynephronrenal capsuleglomerulushighly
    Visualeyeretina  predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • Ras superfamily of GTP-binding proteins
  • RAB guanosine triphosphatase (GTPase) family of vesicle transport proteins
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • involved in small GTPase mediated signal transduction and intracellular protein transportation
  • participate in central nervous system development
  • acts as a negative regulator of hedgehog (HH) signaling
  • having a function in antagonizing sonic hedgehog signal transduction
  • may play a role in protein turnover in the cilium
  • negatively regulates GLI1 activity in a SUFU-dependent manner
  • is an essential component of the mechanism that transmits asymmetric patterning information from the node to the lateral plate mesoderm (LPM)
  • small guanine nucleotide binding protein that has important effects on physiological signaling from cilia but was not known previously to be essential for ciliary delivery of any cargo
  • dopamine receptors reveal a previously unrecognized mechanism of ciliary receptor targeting and functional role of RAB23 in promoting this process
  • promotes squamous cell carcinoma cells migration and invasion by regulating ITGB1/TIAM1/RAC1 pathway
  • serves as an important oncoprotein in human astrocytoma by regulating cell invasion and migration through RAC1 activity
  • role for RAB23 in transport processes to the primary cilium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly associates with SUFU and inhibits GLI1 function in a SUFU-dependent manner
  • KIF17 needs to bind to regulatory proteins like RAB23 for its ciliary transport, and RAB23 could mediate the transport of KIF17 to the primary cilium
  • cell & other
  • interaction with cilia
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACPS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in primary gastric tumors
    tumoral     --over  
    in Prostate cancer tissues and cell lines
    tumoral     --over  
    facilitates malignant cell growth and invasion in bladder cancer through the NFKB1 pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as a biomarker that indicates the severity of FSGS
  • RAB23 expression is a useful indicator of metastatic potential for pancreatic duct adenocarcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    is a potential therapeutic target for PCa treatment
    cancerendocrinepancreas
    may be a new therapeutic target for pancreatic duct adenocarcinoma
    ANIMAL & CELL MODELS