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FLASH GENE
Symbol RAB21 contributors: mct/npt - updated : 11-03-2016
HGNC name RAB21, member RAS oncogene family
HGNC id 18263
Location 12q21.1      Physical location : 72.148.657 - 72.181.149
Synonym name Ras-related protein Rab-21
Synonym symbol(s) KIAA0118
DNA
TYPE functioning gene
STRUCTURE 32.50 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
MAPPING cloned Y linked N status provisional
Physical map
SLC35E3 12q15 solute carrier family 35, member E2 PRO2268 12q14.3 hypothetical protein PRO2268 MDM2 12q14.3-q15 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) MGC5370 12q14.3 hypothetical protein MGC5370 CPM 12q15 carboxypeptidase M CPSF6 12q13.2 cleavage and polyadenylation specific factor 6, 68kDa LYZ 12q14-q15 lysozyme (renal amyloidosis) GAS41 12q13-q15 lysozyme (renal amyloidosis) FRS2 12q15 fibroblast growth factor receptor substrate 2 CCT2 12q15 chaperonin containing TCP1, subunit 2 (beta) LOC387868 12 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 VMD2L3 12q14.2-q15 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 MGC13168 12q14.3 hypothetical protein MGC13168 RAB3IP 12q13-q15 RAB3A interacting protein (rabin3) FLJ25056 12q14.3 hypothetical protein FLJ25056 CNOT2 12q13.2 CCR4-NOT transcription complex, subunit 2 KCNMB4 12q14.1-q15 potassium large conductance calcium-activated channel, subfamily M, beta member 4 LOC390342 12 similar to Gag-Pro-Pol-Env protein PTPRB 12q15 protein tyrosine phosphatase, receptor type, B PTPRR 12q13.2-q13.3 protein tyrosine phosphatase, receptor type, R TM4SF3 12q14.1-q21.1 transmembrane 4 superfamily member 3 GPR49 12q22-q23 G protein-coupled receptor 49 MGC23401 12q15 hypothetical protein MGC23401 DKFZP564I0422 12q15 hypothetical protein DKFZp564I0422 FLJ10936 12q15 hypothetical protein FLJ10936 RAB21 12q13.3 RAB21, member RAS oncogene family FLJ12085 TPH2 12q15 tryptophan hydroxylase 2 TRHDE 12q15-q21 Homo sapiens thyrotropin-releasing hormone degrading ectoenzyme (TRHDE), mRNA. VENTX2P3 12q15 VENT-like homeobox 2 pseudogene 3 LOC387869 12 LOC387869 LOC390343 12 similar to microtubule-associated proteins 1A/1B light chain 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2627 25 225 - 2006 16754960
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Endocrinepancreas   highly
Nervousbrainlimbic systemhippocampus   Homo sapiens
Reproductivemale systemprostate  highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
interspecies homolog to Drosophila CG7646
homolog to C.elegans ncs-2
Homologene
FAMILY
  • RAS superfamily
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text
  • associated with the Golgi apparatus
  • ANKRD27, VAMP7 and RAB21 co-localize in the perinuclear region of differentiating hippocampal neurons and transiently in transport vesicles in the shaft of neurites
  • basic FUNCTION
  • playing a role in the regulation of vesicular transport in polarized intestinal epithelial cells
  • regulates cell adhesion and controls endosomal traffic of beta1-integrins
  • regulating endo/exocytic trafficking of integrins (
  • RAB21 activity, integrin-RABb21 association, and integrin endocytosis are all necessary for normal cytokinesis, which becomes impaired when integrin-mediated adhesion at the cleavage furrow fails
  • RAB21-regulated integrin trafficking is essential for normal cell division, and its defects may contribute to multinucleation and genomic instability, which are hallmarks of cancer
  • regulates SSTR3 trafficking, suggesting that it may play a role in trafficking of other G protein-coupled receptors
  • enhanced the degradation of EGFR through accelerating its internalization in both EGF-independent and EGF-dependent manners
  • plays a negative role in the EGF-mediated MAPK signaling pathway (
  • regulates the dynamic process of sorting cargoes from early endosomes to late endosomes/lysosomes
  • SBF2 and RAB21 have conserved functions required for starvation-induced autophagy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • interacting with ANKRD27 (functions as a Guanine nucleotide exchange factor for RAB21)
  • interacting with the cytoplasmic domains of alpha-integrin chains, and its expression influences the endo/exocytic traffic of integrins
  • RASA1 interacted with the cytoplasmic domain of integrin alpha-subunits via its GAP domain and competed with RAB21 for binding to endocytosed integrins
  • SBF2 is a critical coordinator of PI(3)P and RAB21 regulation, which specifies an endosomal pathway and cortical control
  • SBF2 is required for RAB21 activation, VAMP8 interaction and VAMP8 endolysosomal trafficking, defining a novel GEF-Rab-effector pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS