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FLASH GENE
Symbol RAB1B contributors: mct - updated : 26-08-2016
HGNC name RAB1B, member RAS oncogene family
HGNC id 18370
Location 11q13.2      Physical location : 66.036.055 - 66.044.961
Synonym name small GTP-binding protein
DNA
TYPE functioning gene
STRUCTURE 8.91 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1955 22 201 - 2007 17429068
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Cardiovascularheart    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumcardiac  
cell lineage
cell lines melanoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ATP/GTP binding site
  • HOMOLOGY
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab-GTPase family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • small GTPase, involved in transfer from ER to Golgi
  • role of RAB1B in antibacterial autophagy was independent of its role in ER-to-Golgi transport
  • is required for ER to Golgi transport and interacts with multiple effectors localized at the ER-Golgi interface
  • MTMR6 and RAB1B are involved in tube formation
  • is essential for endoplasmic reticulum-Golgi transport
  • changes in RAB1B levels modulate gene transcription, strongly suggesting that a RAB1B increase is required to elicit a secretory response
  • RAB1B is associated with ATG9A vesicles and regulates autophagosome formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • recruiting P115 to coat protein complex II (COPII) vesicles where P forms a cis-SNARE complex that promotes targeting to the Golgi apparatus
  • cellular localization of MTMR6 is regulated by RAB1B in the early secretory and autophagic pathways
  • recruits RAB1B to the Golgi network to drive malignant secretion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS