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FLASH GENE
Symbol RAB1A contributors: mlc - updated : 27-04-2015
HGNC name RAB1A, member RAS oncogene family
HGNC id 9758
Location 2p14      Physical location : 65.313.988 - 65.357.435
Synonym name
  • GTP binding protein Rab1a
  • Rab GTPase YPT1 homolog
    • Synonym symbol(s) RAB1, YPT1
    DNA
    TYPE functioning gene
    STRUCTURE 43.45 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2420 - 129 - 2000 10903204
    6 - 2648 22 205 - 2000 10903204
    - - 1190 - - - 2000 10903204
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   highly
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   highly
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ATP/GTP binding site
  • a pleckstrin homology domain (PH)
    • HOMOLOGY
    Homologene
    FAMILY
  • RAS-GTPase superfamily
  • RAB subfamily
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • localized to early and late endocytic vesicles
    • basic FUNCTION
  • small GTPase, involved in transfer from ER to Golgi
  • RAB1A and RAB43 are key Rabs required for the biogenesis and maintenance of a functional Golgi structure, and suggest that other Rabs acting at the Golgi complex are likely to be functionally redundant
  • RAB1A and RAB6 may be involved in the regulation of the retinal adaptation
  • well characterized function in the regulation of vesicle trafficking from the endoplasmic reticulum to the Golgi apparatus and within Golgi compartments
  • novel function in the regulation of cell migration through controlling integrin beta1 recycling and localization to lipid rafts via a specific downstream effector pathway
  • regulates phenotypic modulation of pulmonary artery smooth muscle cells by mediating the transport of angiotensin II type 1 receptor under hypoxia
  • regulates minus-end-directed motility largely by recruiting KIFC1 to early endocytic vesicles
  • phosphocholination of RAB1A and RAB35 represents a mechanism by which bacterial FIC-domain-containing proteins can alter host-cell functions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
  • new signaling pathway that involves RAB1A and controls the actin cytoskeleton and pseudopod extension, and thereby, cell polarity and motility
  • phosphocholination of RAB1A and RAB35 represents a mechanism by which bacterial FIC-domain-containing proteins can alter host-cell functions
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
    GTP binding
    protein
  • recruiting P115 to coat protein complex II (COPII) vesicles where P115 forms a cis-SNARE complex that promotes targeting to the Golgi apparatus
  • interactions of GOLGA2 with STX5 and RAB1A are also regulated by mitotic phosphorylation, which is likely to contribute to the inhibition of ER to Golgi trafficking that occurs when mammalian cells enter mitosis
  • interaction of RAB1A and its regulator ARL6IP5 are involved in trafficking and neuronal differentiation
  • LRRK2 binds the small GTPase Rab1A as well as the F-actin cross-linking protein filamin (actin-binding protein 120, abp120)
  • HSPA8 interacted with RAB1A in a chaperone-dependent manner
  • RAB1A stimulated the formation and elongation of WHAMM-associated membrane tubules in cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS