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FLASH GENE
Symbol RAB14 contributors: mct - updated : 04-05-2014
HGNC name RAB14, member RAS oncogene family
HGNC id 16524
Location 9q33.2      Physical location : 123.940.415 - 123.964.365
Synonym symbol(s) FBP, RAB-14
DNA
TYPE functioning gene
STRUCTURE 23.95 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 4374 - 215 - 2004 15004230
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinepancreas   highly
Nervousbrain   highly
 spinal cord   highly
Reproductivemale systemprostate  lowly
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP , Other
HOMOLOGY
interspecies homolog to rattus Rab14 (99.53 pc)
homolog to murine Rab14 (100.00 pc)
Homologene
FAMILY
  • RAS superfamily
  • RAB subfamily
  • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    text
  • localizes to early endosomes and the trans-Golgi network (
  • basic FUNCTION
  • involved in vesicular trafficking and neurotransmitter release
  • involved in membrane trafficking between the Golgi complex and endosomes
  • specifically regulates delivery of cargo from the TGN to the apical domain, and apical targeting in polarized epithelial cells
  • required for recruitment of RUFY1 onto endosomal membranes, and subsequent RUFY1 interaction with RAB4A may allow endosomal tethering and fusion
  • RAB14 and RAB4 regulate endosomal functions through cooperative interactions with their dual effector, RUFY1
  • DENND6A, DENND6B and RAB14 therefore define an endocytic recycling pathway needed for ADAM protease trafficking and regulation of cell-cell junctions
  • RAB10 is likely involved in insulin-stimulated translocation of SLC2A4 storage vesicle (GSV) to the Plasma membrane, with RAB14 involved in insulin-stimulated translocation of SLC2A4-containing endosome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling neurotransmission
    neurotransmitter release
    a component
  • KIF16B/RAB14 complex acts in biosynthetic Golgi-to-endosome traffic of the fibroblast growth factor receptor (FGFR) during early embryonic development
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • binds in a GTP-dependent manner to RUFY1, which had been originally identified as a RAB4A effector
  • in muscle cells, might be a more direct target of TBC1D1 compared with RAB8A
  • RAB10 and RAB14 mediate insulin-stimulated SLC2A4 translocation, respectively, of SLC2A4 storage vesicle (GSV) and endosomal compartments
  • MYO5A is necessary for maintaining a peripheral distribution of RAB11- and RAB14-positive endosomes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS