SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic
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text
| localizes to early endosomes and the trans-Golgi network ( |
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basic FUNCTION
| involved in vesicular trafficking and neurotransmitter release |
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involved in membrane trafficking between the Golgi complex and endosomes |
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specifically regulates delivery of cargo from the TGN to the apical domain, and apical targeting in polarized epithelial cells |
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required for recruitment of RUFY1 onto endosomal membranes, and subsequent RUFY1 interaction with RAB4A may allow endosomal tethering and fusion |
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RAB14 and RAB4 regulate endosomal functions through cooperative interactions with their dual effector, RUFY1 |
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DENND6A, DENND6B and RAB14 therefore define an endocytic recycling pathway needed for ADAM protease trafficking and regulation of cell-cell junctions |
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RAB10 is likely involved in insulin-stimulated translocation of SLC2A4 storage vesicle (GSV) to the Plasma membrane, with RAB14 involved in insulin-stimulated translocation of SLC2A4-containing endosome |
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