basic FUNCTION
| GTPase, cycling between cytosolic and membrane-bound forms |
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specific regulator of vesicular trafficking |
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specifically mediates the endocytic recycling of occludin |
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specifically mediating the continuous endocytic recycling of occludin to the cell surface in both fibroblastic and epithelial cell |
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RAB13 and MICALL2 are involved in epithelial cell scattering |
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with MICALL2, mediated the endocytic recycling of an integral tight junctions (TJ) protein occludin and the formation of functional TJs |
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appears to regulate membrane trafficking between TGN and recycling endosomes |
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guanosine triphosphatase (GTPase) known to participate in tight junction function in other epithelia-also participates in the dynamics of the ectoplasmic specialization, a testis-specific type of anchoring junction |
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potentially functioning in ectoplasmic specialization dynamics in the testis |
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RAB13 and MICALL2 may potentially act to transfer actinin-4 from the cell body to the tips of neurites, where actinin-4 is involved in the reorganization of the actin cytoskeleton which results in neurite outgrowth |
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participates in the regulation of insulin-stimulated SLC2A4 exocytic traffic in a manner not functionally redundant with RAB8A |
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may potentially regulate SLC2A4 vesicles at the level of fusion with the plasma membrane |
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appears to be the latest-acting signal known to date in the insulin signaling cascade, predicted to regulate an insulin-regulated step near/at the cell surface of muscle cells |
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essential component of insulin-stimulated traffic of SLC2A4 in muscle cells |
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RAB13 and RAB8A are Rab-GTPases activated by insulin, and downstream of TBC1D4 they regulate traffic of SLC2A4 vesicles, possibly acting at distinct steps and sites |
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RAB13 and MICALL2 regulate likely reorganization of the actin cytoskeleton throughout epithelial junctional development from establishment to maturation of cell-cell adhesion |
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role of RAB13 as a potent driver of cancer progression |
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translation of RAB13 in specific subcellular environments imparts the protein with distinct properties and highlights a means of controlling protein function through local RNA translation |
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has a critical role in endosomal trafficking to the lateral plasma membrane and is involved in modulation of the tight junction in several cell types |
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potential involvement of RAB13 in relocalisation of desmoglein-2 and formation of giant desmosomes in the apical part of the lateral plasma membrane at the time of uterine receptivity |