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FLASH GENE
Symbol RAB13 contributors: mct - updated : 14-09-2022
HGNC name RAB13, member RAS oncogene family
HGNC id 9762
Location 1q21.3      Physical location : 153.954.127 - 153.958.806
Synonym name
  • RAS-associated protein RAB13
  • growth-inhibiting gene 4 protein
  • Synonym symbol(s) GIG4
    DNA
    TYPE functioning gene
    STRUCTURE 4.68 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1211 22.8 203 - 2008 18779367
    EXPRESSION
    Rna function RAB13 mRNA is expressed in muscle and fat
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal coiled-coil domain, interacting with MICALL2
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • partially colocalizes with TGOLN2 at the TGN and transferrin receptors in recycling endosomes
  • basic FUNCTION
  • GTPase, cycling between cytosolic and membrane-bound forms
  • specific regulator of vesicular trafficking
  • specifically mediates the endocytic recycling of occludin
  • specifically mediating the continuous endocytic recycling of occludin to the cell surface in both fibroblastic and epithelial cell
  • RAB13 and MICALL2 are involved in epithelial cell scattering
  • with MICALL2, mediated the endocytic recycling of an integral tight junctions (TJ) protein occludin and the formation of functional TJs
  • appears to regulate membrane trafficking between TGN and recycling endosomes
  • guanosine triphosphatase (GTPase) known to participate in tight junction function in other epithelia-also participates in the dynamics of the ectoplasmic specialization, a testis-specific type of anchoring junction
  • potentially functioning in ectoplasmic specialization dynamics in the testis
  • RAB13 and MICALL2 may potentially act to transfer actinin-4 from the cell body to the tips of neurites, where actinin-4 is involved in the reorganization of the actin cytoskeleton which results in neurite outgrowth
  • participates in the regulation of insulin-stimulated SLC2A4 exocytic traffic in a manner not functionally redundant with RAB8A
  • may potentially regulate SLC2A4 vesicles at the level of fusion with the plasma membrane
  • appears to be the latest-acting signal known to date in the insulin signaling cascade, predicted to regulate an insulin-regulated step near/at the cell surface of muscle cells
  • essential component of insulin-stimulated traffic of SLC2A4 in muscle cells
  • RAB13 and RAB8A are Rab-GTPases activated by insulin, and downstream of TBC1D4 they regulate traffic of SLC2A4 vesicles, possibly acting at distinct steps and sites
  • RAB13 and MICALL2 regulate likely reorganization of the actin cytoskeleton throughout epithelial junctional development from establishment to maturation of cell-cell adhesion
  • role of RAB13 as a potent driver of cancer progression
  • translation of RAB13 in specific subcellular environments imparts the protein with distinct properties and highlights a means of controlling protein function through local RNA translation
  • has a critical role in endosomal trafficking to the lateral plasma membrane and is involved in modulation of the tight junction in several cell types
  • potential involvement of RAB13 in relocalisation of desmoglein-2 and formation of giant desmosomes in the apical part of the lateral plasma membrane at the time of uterine receptivity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RAB13-MICALL2 system may be involved in the formation of cell-cell adhesions via transport of adhesion molecules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of MICALL2 with RAB8A and RAB13 coordinates the assembly of adherens junctions and tight junctions
  • MICALL2 is a RAB13 effector protein (intramolecular interaction between the N-terminal calponin-homology (CH) and LIM domains of JRAB/MICAL-L2 and the C-terminal coiled-coil domain)
  • RAB35 functions as a master RAB that determines the intracellular localization of MICALL1, which in turn functions as a scaffold for RAB8A, RAB13, and RAB36
  • ST5 is the guanine nucleotide exchange factor for RAB13
  • MICALL2 is an effector of insulin-activated RAB13, which links to SLC2A4 through ACTN4, localizing SLC2A4 vesicles at the muscle cell periphery to enable their fusion with the membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    present in apical tight junctions in normal epithelium but were dislocated to the basolateral position in patients with inactive Crohn disease (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    Targeting Rab13 perturbs formation of the breast cancer stem cell niche by inhibiting cross-talk between cancer cells and the tumor microenvironment, providing a therapeutic opportunity for niche-targeted breast cancer treatment
    cancer  
    blocking RAB13 activation by ST5 may provide a novel target to limit the spread of epithelial cancers
    ANIMAL & CELL MODELS