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FLASH GENE
Symbol RAB13 contributors: mct - updated : 06-05-2011
HGNC name RAB13, member RAS oncogene family
HGNC id 9762
Location 1q21.2      Physical location : 153.954.127 - 153.958.806
Synonym name
  • RAS-associated protein RAB13
  • growth-inhibiting gene 4 protein
  • Synonym symbol(s) GIG4
    DNA
    TYPE functioning gene
    STRUCTURE 4.68 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    S100A15 1q22 S100 calcium binding protein A15 S100A7L2 1q22 S100 calcium binding protein A7-like 2 S100A7 1q21 S100 calcium binding protein A7 (psoriasin 1) S100A6 1q21 S100 calcium binding protein A6 (calcyclin) S100A5 1q21 S100 calcium binding protein A5 S100A4 1q21 S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) LOC388700 1 hypothetical gene supported by BT006955; NM_002960 S100A2 1q21 S100 calcium binding protein A2 S100A1 1q21 S100 calcium binding protein A1 DKFZP547E1010 1q22 DKFZP547E1010 protein SNAPAP 1q22 SNAP-associated protein ILF2 1q21.1 interleukin enhancer binding factor 2, 45kDa NPR1 1q21.1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) FLJ21919 1q22 hypothetical protein FLJ21919 SLC27A3 1q21.1 solute carrier family 27 (fatty acid transporter), member 3 LOC343052 1q22 similar to putative neuronal cell adhesion molecule P66beta 1q22 transcription repressor p66 beta component of the MeCP1 complex KIAA0476 1p36.13-q31.3 transcription repressor p66 beta component of the MeCP1 complex LOC200186 1q22 hypothetical protein LOC200186 SLC39A1 1q21 solute carrier family 39 (zinc transporter), member 1 CREB3L4 1q21.2 cAMP responsive element binding protein 3-like 4 JTB 1q21 jumping translocation breakpoint RAB13 12q13 RAB13, member RAS oncogene family RPS27 1q21 ribosomal protein S27 (metallopanstimulin 1) LOC91181 1q22 nuclear pore membrane glycoprotein 210-like TPM3 1q22-q23 tropomyosin 3 LOC388701 1 LOC388701 NICE-3 1q21.2 NICE-3 protein NICE-4 1q22 NICE-4 protein HAX1 1q21 NICE-4 protein AQP10 1q21.2 aquaporin 10 ATP8B2 1q21.2 ATPase, Class I, type 8B, member 2 MRPS33P1 1q21.3 mitochondrial ribosomal protein S33 pseudogene 1 LOC388702 1 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) IL6R 1q21 interleukin 6 receptor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1211 22.8 203 - 2008 18779367
    EXPRESSION
    Rna function RAB13 mRNA is expressed in muscle and fat
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousnerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal coiled-coil domain, interacting with MICALL2
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • partially colocalizes with TGOLN2 at the TGN and transferrin receptors in recycling endosomes
  • basic FUNCTION
  • GTPase, cycling between cytosolic and membrane-bound forms
  • specific regulator of vesicular trafficking
  • specifically mediates the endocytic recycling of occludin
  • specifically mediating the continuous endocytic recycling of occludin to the cell surface in both fibroblastic and epithelial cell
  • RAB13 and MICALL2 are involved in epithelial cell scattering
  • with MICALL2, mediated the endocytic recycling of an integral tight junctions (TJ) protein occludin and the formation of functional TJs
  • appears to regulate membrane trafficking between TGN and recycling endosomes
  • guanosine triphosphatase (GTPase) known to participate in tight junction function in other epithelia-also participates in the dynamics of the ectoplasmic specialization, a testis-specific type of anchoring junction
  • potentially functioning in ectoplasmic specialization dynamics in the testis
  • RAB13 and MICALL2 may potentially act to transfer actinin-4 from the cell body to the tips of neurites, where actinin-4 is involved in the reorganization of the actin cytoskeleton which results in neurite outgrowth
  • participates in the regulation of insulin-stimulated SLC2A4 exocytic traffic in a manner not functionally redundant with RAB8A
  • may potentially regulate SLC2A4 vesicles at the level of fusion with the plasma membrane
  • appears to be the latest-acting signal known to date in the insulin signaling cascade, predicted to regulate an insulin-regulated step near/at the cell surface of muscle cells
  • essential component of insulin-stimulated traffic of SLC2A4 in muscle cells
  • RAB13 and RAB8A are Rab-GTPases activated by insulin, and downstream of TBC1D4 they regulate traffic of SLC2A4 vesicles, possibly acting at distinct steps and sites (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of MICALL2 with RAB8A and RAB13 coordinates the assembly of adherens junctions and tight junctions
  • MICALL2 is a RAB13 effector protein (intramolecular interaction between the N-terminal calponin-homology (CH) and LIM domains of JRAB/MICAL-L2 and the C-terminal coiled-coil domain)
  • RAB35 functions as a master RAB that determines the intracellular localization of MICALL1, which in turn functions as a scaffold for RAB8A, RAB13, and RAB36
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS