Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RAB11FIP3 contributors: mct - updated : 23-09-2014
HGNC name RAB11 family interacting protein 3 (class II)
HGNC id 17224
Location 16p13.3      Physical location : 475.667 - 572.480
Genatlas name arfophilin
Synonym name
  • Rab11 and ADP-ribosylation factor (ARF) binding protein
  • EF-hands -containing RAB11-interacting protein (eferin )
  • arfophilin-1
  • cytoplasmic adaptor for RAR and TR
  • rab11-family interacting protein 3
  • Synonym symbol(s) KIAA0665, RAB11-FIP3, CART1, FIP3
    EC.number 2.7.4.6
    DNA
    TYPE functioning gene
    STRUCTURE 100.36 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4273 - 756 - 2005 16473615
    - - 3227 - 460 - 2005 16473615
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemuterus   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two EF-hand- calcium binding domains
  • myosin tail
  • C terminal domain necessary for RAB11 binding
  • HOMOLOGY
    interspecies homolog to C.elegans F55C12
    Homologene
    FAMILY ezrin/radixin/moesin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • colocalises with RAB11 in a distinctive pericentrosomal location (localisation is dependent on both microtubule and actin filament integrity)
  • RAB11FIP3 localization to recycling endosomes in interphase and their transport to the intercellular bridge during cytokinesis depend on RAB11A
  • dephosphorylation of RAB11FIP3 accompanies its translocation from the cytosol to membranes during telophase
  • basic FUNCTION
  • playing a role in endosomal
  • recycling, phagocytosis, transport of secretory protein from the trans-Golgi network
  • endosomal recycling compartment (ERC) protein that is implicated in the process of membrane delivery from the ERC to sites of membrane insertion during cell division
  • is necessary for the structural integrity of the pericentrosomal ERC
  • RAB11FIP3, RAB11FIP4 are involved in the transport of endosomally derived membrane to the cleavage furrow during cytokinesis
  • is a scaffolding protein that, in addition to regulating endosome targeting to the cleavage furrow, also is required for ARF6 recruitment to the midbody during late telophase
  • RAB11FIP3 protein complex have emerged as a regulator of endocytic traffic, essential for the abscission step in cytokinesis
  • dual effector of RAB11A and ARF6 that exhibits RAB11A-dependent localization to recycling endosomes in interphase
  • controls recycling endosome distribution during interphase
  • is a cell cycle regulated phosphoprotein, suggesting dephosphorylation of RAB11FIP3 accompanies its translocation from the cytosol to membranes during telophase
  • RAB11FIP3 acts synergistically with ASAP1 to direct RAB3IP in ciliary receptor targeting
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB11FIP4 interacts with RAB11A in a GTP-dependent manner and its C-terminal region allows the protein to self-interact and interact with RAB11FIP5, RAB11FIP2, and RAB11FIP3
  • is the first membrane-associated interacting-partner for DYNC1LI2 and this interaction potentially serves to control endosomal trafficking from sorting endosomes to the endosomal-recycling compartment (ERC)
  • TSG101 is a novel RAB11FIP4-binding protein, which we find can also bind RAB11FIP3
  • RAB11FIP3 coordinates the interactions of ASAP1 and RAB11A with RAB3IP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS