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FLASH GENE
Symbol RAB11FIP2 contributors: mct - updated : 17-01-2015
HGNC name RAB11 family interacting protein 2 (class I)
HGNC id 29152
Location 10q26.12      Physical location : 119.764.428 - 119.806.114
Synonym name
  • rab 11-family interacting protein 2
  • related to TYL protein
  • Synonym symbol(s) KIAA0941, RAB11-FIP2, nRip11
    DNA
    TYPE functioning gene
    STRUCTURE 41.87 kb     5 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 6077 - 512 - 2006 16775013
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Hearing/Equilibriumear   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to TYL protein
    Homologene
    FAMILY RAB11interacting protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • RAB11A, MYO5B, RAB11FIP2 regulate plasma membrane recycling in epithelial cells
  • regulates trafficking at multiple points within the apical recycling system of polarized cells
  • critical role for the interaction of MYO5B with RAB11FIP2 in stabilizing the functional complex with RAB11A, which regulates dynamic movements of membrane recycling vesicles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MYO5B/RAB11A/RAB11FIP2 platform is spatially involved in the regulation of CD207 trafficking at two distinct sites within live cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EHD proteins (mediating endocytic recycling)
  • contains an NPF motif that allows it to bind REPS1, a member of a family of EH domain proteins involved in endocytosis
  • RAB11FIP4 interacts with RAB11A in a GTP-dependent manner and its C-terminal region allows the protein to self-interact and interact with RAB11FIP5, RAB11FIP2, and RAB11FIP3
  • SEMA4A plays a role in RAB11FIP2-mediated endosomal sorting in retinal pigment epithelial cells to support photoreceptor function
  • tripartite association of RAB11A with both RAB11FIP2 and MYO5B regulates recycling endosome trafficking
  • cell & other
    REGULATION
    Phosphorylated by on serine 227 by MARK2 regulates an alternative pathway modulating the establishment of epithelial polarity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS