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Symbol RAB11FIP1 contributors: mct/npt - updated : 25-08-2008
HGNC name RAB11 family interacting protein 1 (class I)
HGNC id 30265
Location 8p11.22      Physical location : 37.716.465 - 37.757.015
Synonym name Rab coupling protein
Synonym symbol(s) RCP, FLJ22524, FLJ22622, RAB11-FIP1, NOEL1A, MGC78448, DKFZp686E2214
DNA
TYPE functioning gene
STRUCTURE 39.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text
  • splice variants using alternative 5-prime start sites
  • eight alternatively spliced Rab11-FIP1 gene transcripts from chromosome 8
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 4222 71 649 - Goldenring (2004), Ewing (2007)
    3 splicing 4557 - 612 - Goldenring (2004), Ewing (2007)
    6 splicing 7839 - 1283 - Goldenring (2004), Ewing (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestine   highly
    Endocrinepancreas    
    Lymphoid/Immunelymph node   highly
    Respiratorylung    
     respiratory tracttrachea  highly
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one C2 phospholipid-binding domain
  • two putative coiled-coil domains
  • HOMOLOGY
    interspecies homolog to rabbit rab11fip1
    Homologene
    FAMILY
  • RAB11 interacting protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in regulation of Rab GTPases
  • have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles
  • may play coordinated roles in regulating plasma membrane recycling with regional specificity within the RAB11A-containing recycling system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Rab GTPases
  • binds to RAB11A and RAB11B through a carboxyl-terminal amphipathic alpha helix
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS