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FLASH GENE
Symbol RAB11B contributors: mct - updated : 02-02-2017
HGNC name RAB11B, member RAS oncogene family
HGNC id 9761
Corresponding disease
Location 19p13.2      Physical location : 8.455.204 - 8.469.315
Synonym name
  • GTP-binding protein YPT3
  • ras-related protein Rab-11B
  • Synonym symbol(s) H-YPT3, MGC133246
    DNA
    TYPE functioning gene
    STRUCTURE 14.11 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC41903 STXBP2 19p13.3-p13.2 syntaxin binding protein 2 RETN 19p13.3 resistin LOC199675 19p13.3 hypothetical protein LOC199675 TRAPPC5 19p13.3 trafficking protein particle complex 5 FCER2 19p13.3 Fc fragment of IgE, low affinity II, receptor for (CD23A) UNQ431 19p13.3 DTTR431 CD209 19p13 CD209 antigen CD209L 19p13.3 CD209 antigen-like LOC390879 19 similar to DTTR431 LOC115704 19p13.3 similar to ecotropic viral integration site 5; Neuroblastoma stage 4S gene LOC388499 19 similar to lysophospholipase II; acyl-protein thioesterase FLJ23420 19p13.3 hypothetical protein FLJ23420 MAP2K7 19p13.2 mitogen-activated protein kinase kinase 7 LOC388500 19 LOC388500 SNAPC2 19q13.3-p13.2 small nuclear RNA activating complex, polypeptide 2, 45kDa TIMM44 19p13.3-p13.2 translocase of inner mitochondrial membrane 44 homolog (yeast) ELAVL1 19p13.2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) CCL25 19p13.2 chemokine (C-C motif) ligand 25 FBN3 19p13 fibrillin 3 LASS4 19p13.3 LAG1 longevity assurance homolog 4 (S. cerevisiae) 8D6A 19p13.3-p13.2 LAG1 longevity assurance homolog 4 (S. cerevisiae) NDUFA7 19p13.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa RPS28 19p13.2 ribosomal protein S28 FLJ46061 19p13.3 FLJ46061 protein ANGPTL4 19p13.3 angiopoietin-like 4 RAB11B 19p13.3 RAB11B, member RAS oncogene family LOC51257 19p13.3 hypothetical protein LOC51257 HNRPM 19p13.3 heterogeneous nuclear ribonucleoprotein M PRAM-1 19p13.3 PRAM-1 protein MGC15716 19p13.3 hypothetical protein MGC15716 MYO1F 19p13.3-p13.2 myosin IF ADAMTS10 19p13.3 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10 LOC390880 19 similar to nuclear factor, interleukin 3, regulated MGC33407 19p13.2 hypothetical protein MGC33407 LOC390881 19 similar to 60S ribosomal protein L23a LOC284383 19p13.2 similar to Olfactory receptor 2Z1 FLJ30932 19p13.2 hypothetical protein FLJ30932 MBD3L1 19p13.3 methyl-CpG binding domain protein 3-like 1 LOC388501 19 hypothetical gene supported by AF414442; AK024365; AK056791; AK128856
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1635 - 218 - 2003 14627637
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheartventricle    Homo sapiens
    Digestivesalivary gland   highly Homo sapiens
    Nervousbrain   predominantly Homo sapiens
     nervecranial nerve  highlyHomo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiacmyocardium  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
      
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four conserved domains important for GTP binding the C terminus involved in membrane association
  • conjugated LipoP , Other
    HOMOLOGY
    interspecies homolog to murine Rab11b
    homolog to Drosophila rab11
    homolog to C.elegans rab11.1
    homolog to yeast ypt3
    intraspecies homolog to RAB11A
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localized to peri-centrosomal recycling endosomes concentrated at the base of the cilium
  • basic FUNCTION
  • involved in vesicle transport
  • having GTPase activity
  • having a specific role in neuronal and neuroendocrine but not in non-neuronal cells as a GTP-dependent switch between regulated and constitutive secretory pathways
  • having divergent functions in Ca2+-regulated versus constitutive exocytosis
  • implicated in the regulation of vesicular trafficking between the recycling endosome compartment and early endosomes to the trans Golgi network and plasma membrane
  • regulates apical recycling in polarized epithelial cells
  • RAB11B is a crucial regulator and RAB11FIP5 is a mediator of acidosis-induced V-ATPase traffic in duct cells of submandibular gland
  • regulator of endosomal recycling
  • differentially regulates the trafficking of distinct cargo and extends our understanding of how endosomal transport impacts the functional expression of L-type Ca(2+) channels
  • regulates the trafficking and recycling of SCNN1A
  • predominant mechanism of melanin transfer is keratinocyte-induced exocytosis, mediated by RAB11B through remodeling of the melanosome membrane, followed by subsequent endocytosis by keratinocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • RAB11B is necessary for the trafficking of PRKG2 and the cGMP/PRKG2 signaling pathway is closely related to RAB11B recycling pathway
  • RAB11B and its effector RAB11FIP5 participate in insulin granule exocytosis and RAB11FIP5, as a substrate of PKA, regulates the potentiation of exocytosis by cAMP in pancreatic beta-cells
  • is a crucial regulator and RAB11FIP5 as mediator of acidosis-induced ATP6V1A traffic in duct cells of submandibular gland
  • RAB11B has a moderate association with a region of KCNMA1 that includes AA 127616 and this interaction of RAB11B and KCNMA1 is in cochlea
  • RAB3IL1 is a dual RAB-binding protein that could potentially link RAB3A and RAB11A/RAB11B and/or RAB8A/RAB8B and RAB11-mediated intracellular trafficking processes
  • LZ doamin of PRKG2 specifically interacted with RAB11B
  • RAB11B is a critical regulator of F2R trafficking
  • RAB11A and RAB11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms
  • is a direct interactor of the ciliary RAB RABIN8
  • interaction between TBC1D8B and RAB11B, a key protein in vesicular recycling in cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDASCW
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS