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FLASH GENE
Symbol RAB11A contributors: mct/ - updated : 08-07-2015
HGNC name RAB11A, member RAS oncogene family
HGNC id 9760
Location 15q22.31      Physical location : 66.161.795 - 66.181.791
Synonym name RAS related GTP-binding protein, branch rab, member 11
Synonym symbol(s) MGC1490, YL8, RAB11
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
OAZ2 15q22 ornithine decarboxylase antizyme 2 RBPMS2 15q22.1 RNA-binding protein with multiple splicing 2 FLJ22692 15q22.1 hypothetical protein FLJ22692 pp9099 15q22.1 PH domain-containing protein LOC348094 15q22.2 hypothetical protein LOC348094 ACP33 15q21-q22 hypothetical protein LOC348094 MtFMT 15q22.2 methionyl-tRNA formyltransferase, mitochondrial OSTbeta 15q22.2 organic solute transporter beta RIS LOC390594 15 similar to RIKEN cDNA C230080I20 gene LOC390595 15 similar to ubiquitin associated protein PDCD7 15q22.2 programmed cell death 7 CLPX 15q22.31 ClpX caseinolytic protease X homolog (E. coli) CILP 15q22 cartilage intermediate layer protein, nucleotide pyrophosphohydrolase FLJ20509 15q22.2 hypothetical protein FLJ20509 LOC390596 15 similar to cell division cycle 2-like 1 (PITSLRE proteins) isoform 1; cell division cycle 2-like 1; PITSLRE protein kinase alpha; p58/GTA protein kinase; galactosyltransferase associated protein kinase; CDC-related protein kinase p5 PUNC 15q22.3-q23 putative neuronal cell adhesion molecule NOPE 15q22.2 putative neuronal cell adhesion molecule DPP8 15q22 dipeptidylpeptidase 8 HSPC121 15q22.2 butyrate-induced transcript 1 DKFZP564O1664 15q22.2 hypothetical protein DKFZp564O1664 SLC24A1 15q22 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 IRLB 15q22.2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 LOC388127 15 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) RAB11A 15q21.3-q22.31 RAB11A, member RAS oncogene family MEGF11 15q22.2 MEGF11 protein MGC4562 15q22.2 hypothetical protein MGC4562 FLJ20516 15q22.2 timeless-interacting protein MAP2K1 15q22.1-q22.33 mitogen-activated protein kinase kinase 1 LOC388128 15 similar to ribosomal protein L9; 60S ribosomal protein L9 SNAPC5 15q22.2 small nuclear RNA activating complex, polypeptide 5, 19kDa RPL4 15q22 ribosomal protein L4 FLJ10036 15q22.2 hypothetical protein FLJ10036 MADH6 15q21-q22 MAD, mothers against decapentaplegic homolog 6 (Drosophila) LOC390597 15 similar to leucine zipper-EF-hand containing transmembrane protein 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 polyA site 2393 - 216 - 1998 9662449
large isoform
- polyA site 1000 - - - 1998 9662449
  • smll isoform
  • identical coding sequence
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunespleen   highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text localized to the TGN and recycling endosome and around the base of the primary cilia
    basic FUNCTION
  • GTPase, putatively involved in secretory pathway
  • acting as a mediator of insulin stimulated translocation of the glucose transporter SLC2A4 in peripheral tissues including heart and skeletal muscle
  • regulating the recycling and lysosome targeting of beta2-adrenergic receptors
  • RAB11A, MYO5B, RAB11FIP2 regulate plasma membrane recycling in epithelial cells
  • GTP-bound form, interacts with Rabin8 and kinetically stimulates the guanine nucleotide-exchange activity of Rabin8 toward RAB8A
  • play an important role in controlling vesicular transport from the TGN and the recycling endosomes to the plasma membrane
  • potential RAB11A–RAB8A cascade which may function in primary cilium assembly
  • RAB11A GTPase and its binding protein, RAB11FIP5, are important regulators of polarized endocytic transport
  • TBC1D14- and RAB11A-dependent vesicular transport from recycling endosomes (REs) contributes to and regulates starvation-induced autophagy
  • RAB11A, and RAB25 promote cell migration by regulating vesicular transport and recycling of surface receptors
  • is mainly responsible for basal long-distance transport from the rear end to the front of the migrating cell
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MYO5B/RAB11A/RAB11FIP2 platform is spatially involved in the regulation of CD207 trafficking at two distinct sites within live cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB11FIP5 participates in endosomal recycling through the interaction with both NAPG, a member of the soluble NSF attachment protein family, and RAB11A
  • RAB11FIP3 links the RAB11A GTPase and cytoplasmic dynein to mediate transport of material from peripheral sorting endosomes to the centrally located endosomal-recycling compartment (ERC)
  • direct and highly specific interactant of PTGIR, playing a critical role in its subsequent trafficking after agonist-induced internalization
  • RAB11A and its binding protein, RAB11FIP5, are important regulators of polarized endocytic transport
  • may plays a positive role in the association of BBS1 with Rabin8
  • RAB8A and RAB11A are associated with the BBS pathway
  • RAB8A and RAB8B are recruited by RAB11A after serum starvation for transport to the pericentriolar compartment
  • SNX4 is associated with the RAB11A-recycling endosomes and a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo RAB4A-to-RAB11A transition
  • binding of EXOC6 to both RAB11A and RAB8A serves to coordinate vesicle budding from the recycling endosomes and vesicle tethering at the plasma membrane
  • EVI5 requires its Rab-GAP activity to fulfill its functions during migration and acts as a GAP protein for RAB11A
  • ASAP1 serves as a scaffold that brings together the proteins necessary for transport to the cilia including the GTP-binding protein ARF4 and the two G proteins of the Rab family--RAB11A and RAB8A--linked by the RAB8A guanine nucleotide exchange factor RAB3IP
  • UNC119 plays a key role in the FYN signal transduction pathway, which regulates the completion of cytokinesis via RAB11A
  • FLOT2 directly interacts with RAB11A and SNX4
  • RAB3IL1 is a dual RAB-binding protein that could potentially link RAB3A and RAB11A/RAB11B and/or RAB8A/RAB8B and RAB11-mediated intracellular trafficking processes
  • RAB11A is a novel interaction partner of PKP4
  • tripartite association of RAB11A with both RAB11FIP2 and MYO5B regulates recycling endosome trafficking
  • RAB11FIP3 coordinates the interactions of ASAP1 and RAB11A with RAB3IP
  • GTPase RAB11A, is involved in the recycling of KCNH2
  • RAB11A and RAB11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Developmental and epileptic encephalopathy (DEE)
    Variant & Polymorphism other
  • missense variant in RAB11A (c.244C>T [p.Arg82Cys] associated to DEE
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS